科技部生科司 司長
科技部生科司生化及藥理醫學學門 召集人
行政院生技產業策略諮議委員會議(BTC)委員
經濟部生技醫藥產業發展推動小組委員
衛福部長期照顧諮詢會委員
衛福部癌症防治政策委員會委員
教育部國際數理學科奧林匹亞競賽諮詢會諮詢委員
財團法人農業科技研究院董事
財團法人國家實驗研究院國家實驗動物中心諮議委員
財團法人高等教育評鑑中心基金會委員
財團法人永信李天德醫藥基金會「李天德醫藥科技獎」評審委員會召集人
國立陽明大學生命科學院 院長
國立陽明大學生技醫療EMBA班 主任
國立陽明大學分子醫學博士學位學程 主任
台灣聯合大學系統跨領域神經科學博士學位學程 主任
國際生物化學及分子生物學聯盟(IUBMB) 台灣代表
亞洲及大洋洲生物化學家及分子生物學家聯盟(FAOBMB) 台灣代表
台灣生物化學及分子生物學學會 理事長
台灣生物化學及分子生物學學會 理事、監事
中華民國細胞及分子生物學學會 理事
台灣基因體暨遺傳學會 理事
美國密西根大學醫學系 訪問教授
國立中興大學校友總會 顧問
國立中興大學生命科學院 院長
國立中興大學生物醫學研究所 創所所長
國立中興大學生科中心 組長
國立中興大學生命科學系 副教授、教授
美國康乃爾大學分子醫學系 博士後研究員

榮譽

指導學生獲獎

研究興趣

探討細胞癌化的機轉:
(1) 癌細胞移動的機轉
(2) 中間絲骨架蛋白在細胞癌化過程中的角色

研究著作

Fan, J.-R., Chang, S.-N., Chu, C.-T., and Chen, H.-C.* (2023). AKT2-mediated nuclear deformation leads to genome instability during epithelial-mesenchymal transition. iScience 26:106992

Chen, Y.-H., Hsu, J.-Y., Chu, C.-T., Chang, Y.W., Fan, J.-R., Yang, M.-H., and Chen, H.-C.* (2022). Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation. Life Science Alliance e202201529.

Chu, C.-T., Chen, Y.-H., Chiu, W.-T.,  Chen, H.-C.*  (2021). Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase. Life science alliance, 4(10), e202101120.

Fan, J.-R., You, L.-R., Wang, W.-J., Huang, W.-S., Chu, C.-T., Chi, Y.-H., Chen, H.-C.* (2020). Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis. EMBO Reports, e49680.

Su, C.-Y., Yan, R.-L., Hsu, W.-U., Chu, C.-T., Chang, H.-C., Lai, C.-C., Hsu, H.-P., Chen, H.-C.* (2019). Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration. Scientific Reports 9(1):13703.

Yang, C.-Y., Chang, P.-W., Hsu, W.-H., Chang, H.-C., Chen, C.-L., Lai , C.-C., Chiu, W.-T.,and Chen, H.-C.* (2019). Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration. Oncogene 2019 May ;38(21):4075-4094.

Kuo, S.-L., Chen, C.-L., Pan, Y.-R., Chiu, W.-T., and Chen, H.-C.* (2018). Biogenesis of podosome rosettes through fission. Scientific Reports 8: 524.

Hsu, W., Wang, W., Lin, W., Huang, Y., Lai, C., Liao, J., and Chen, H.-C.* (2018). Adducin‐1 is essential for spindle pole integrity through its interaction with TPX2. EMBO Reports 19(8), e45607.

Liu, C.-M., Hsu, W.-H., Lin, W.-Y., and Chen, H.-C.* (2017). Adducin family proteins possess different nuclear export potentials. Journal of Biomedical Science 24: 30.

Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL.* (2016). HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene 35:5674-5685.

Chen, C.-L., Wang, S.-H., Chan, P.-C., and Chen, H.-C.* (2016). Phosphorylation of E-cadherin at threonine 790 by protein kinase Cd suppresses the function of E-cadherin. Oncotarget 7: 37260-37276.

Tsai, W.-C., Chen, C.-L., and Chen, H.-C.*(2015). Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling. Oncotarget 6:23845-23856.

Chang, C.-H., Chan, P.-C., Li, J.-R., Chen, C.-J., Shieh, J.-J., Fu, Y.-C., Chen, H.-C., and Wu, M-.J.* (2015). Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma. Oncotarget 6:1478-1489.

Chan, P.-C. Hsu, R. Y. C., Liu, C.-W., Lai, C.-C., and Chen, H.-C.* (2014). Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X. Journal of Cell Biology 204:19-28. (highlighted article)

Pan., Y.-R., Tseng, W.-S., Chang, P.-W., and Chen, H.-C.* (2013). Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. Journal of Cell Science 126:5670-5680. (cover article)

Hsieh, Y.-T., Chou, M.–M., Chen, H.-C.,* and Tseng, J.-J.* (2013). IMP1 promotes choriocarcinoma cell migration and invasion through novel effectors RSK2 and PPME1. Gynecological Oncology 131: 182-190.

Pan, Y.-R., Cho, K.-H., Lee, H.-H., Chang, Z.-F., and Chen, H.-C.* (2013). Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts. Journal of Cell Science 126:(2) 657-666.

Chan, P.-C. and Chen, H.-C.* (2012). P120RasGAP-medaited activation of c-Src is critical for oncogenic Ras to induce tumor invasion. Cancer Research72: 2405-2415.

Pan, Y.-R., Chen, C.-L., and Chen, H.-C.* (2011). FAK is required for the assembly of podosome rosettes. Journal of Cell Biology 195: 113-129.

Chen, C.-L., Lin, Y.-P., Lai, Y.-C., and Chen, H.-C.* (2011). a-Adducin translocates to the nucleus upon loss of cell-cell adhesions. Traffic 12: 1327-1340.

Lu, Y.-C. and Chen, H.-C.* (2011). Involvement of lipid rafts in adhesion-induced activation of Met and EGFR. Journal of Biomedical Science 18:78.

Chen, T.-H., Chan, P.-C., Chen, C.-L., and Chen, H.-C.* (2011). Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition. Oncogene 30: 153-166.

Chan, P.-C., Sudhakar, J. N., Lai, C.-C., and Chen, H.-C.* (2010). Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions. Oncogene 29: 698-710.

Chen, C.-L., Chan, P.-C., Wang, S.-H., Pan, Y.-R., and Chen, H.-C.* (2010). Elevated expression of protein kinase Cd induces cell scattering upon serum deprivation. Journal of Cell Science 123: 2901-2913. (highlighted article)

Lee, W.-C., Chen, H.-C., Wang, C.-Y., Lin, P.-Y., Ou, T.-T., Chen, C.-C., Wen, M.-C., Wang, J., and Lee, H.-J.* (2010). Cilostazol ameliorates nephropathy in type I diabetic rats involving in oxidative stress and regulation of TGFb and NFkB.Biosci. Biotechnol. Biochem.74: 1355-1361.