{"id":548,"date":"2025-10-28T09:12:22","date_gmt":"2025-10-28T01:12:22","guid":{"rendered":"https:\/\/biochem.nycu.edu.tw\/%e6%b8%b8%e9%ba%97%e5%a6%82\/"},"modified":"2025-10-28T15:23:33","modified_gmt":"2025-10-28T07:23:33","slug":"you-li-ru","status":"publish","type":"post","link":"https:\/\/biochem.nycu.edu.tw\/english\/faculty\/full-time\/you-li-ru\/","title":{"rendered":"Li-Ru You , PhD , Professor"},"content":{"rendered":"\n
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\u5c08\u9577<\/mark>
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\u8fa6\u516c\u5ba4<\/mark>
\u5716\u8cc7\u5927\u6a13 \u516d\u6a13 R646 \u5ba4<\/h2>\n\n\n\n

\u96fb\u8a71<\/mark>
886-2-28267368<\/h2>\n\n\n\n

Email<\/mark>
lryou@nycu.edu.tw<\/a> <\/h2>\n\n\n\n

ORCiD<\/mark>
0000-0003-1775-0097<\/a><\/h2>\n<\/div>\n<\/div>\n\n\n\n

\u7814\u7a76\u65b9\u5411<\/h1>\n\n\n\n

\u6211\u7684\u5be6\u9a57\u5ba4\u4e3b\u8981\u4ee5\u7d44\u7e54\/\u7d30\u80de\u7279\u7570\u6027\u57fa\u56e0\u5254\u9664\u5c0f\u9f20(conditional knockout mouse)\u70ba\u52d5\u7269\u6a21\u5f0f\uff0c\u63a2\u8a0e\u57fa\u56e0\u5728\u767c\u80b2\u53ca\u764c\u75c7\u5f62\u6210\u6240\u626e\u6f14\u7684\u89d2\u8272\u3002\u5728\u767c\u80b2\u76f8\u95dc\u7684\u7814\u7a76\uff0c\u76ee\u524d\u6709\u5fc3\u81df\u8840\u7ba1\u53ca\u9020\u8840\u5e79\u7d30\u80de\u4e4b\u751f\u9577\u548c\u5206\u5316\u7684\u5c0f\u9f20\u6a21\u5f0f\uff0c\u4f9d\u6240\u89c0\u5bdf\u5230\u7684\u7f3a\u9677\u6027\u72c0\u63a2\u8a0e\u53c3\u8207\u5176\u4e2d\u91cd\u8981\u57fa\u56e0\u8abf\u63a7\u53ca\u8a0a\u606f\u50b3\u5c0e\u3002\u5728\u764c\u75c7\u5f62\u6210\u65b9\u9762\uff0c\u4e3b\u8981\u63a2\u8a0e\u809d\u764c\u7684\u81f4\u75c5\u904e\u7a0b\u53ca\u8a0a\u606f\u50b3\u5c0e\uff0c\u6211\u5011\u4e5f\u5efa\u7acb\u4ee5diethylnitrosamine (DEN)\u8a98\u5c0e\u809d\u764c\u767c\u751f\u7684\u5c0f\u9f20\u6a21\u5f0f\u4f86\u6a21\u64ec\u4eba\u985e\u809d\u764c\u767c\u751f\u7684\u72c0\u6cc1\u3002\u5229\u7528\u7d30\u80de\u7279\u7570\u6027\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\u6a21\u5f0f\uff0c\u6211\u5011\u5206\u6790\u57fa\u56e0\u5728\u809d\u81df\u4e2d\u4e0d\u540c\u985e\u578b\u7684\u7d30\u80de\uff0c\u5305\u62ec\u809d\u7d30\u80de (hepatocyte)\u3001\u809d\u7ac7\u5167\u76ae\u7d30\u80de(liver sinusoidal endothelial cells)\u53ca\u5eab\u4f5b\u6c0f\u7d30\u80de(kupffer cells)\uff0c\u5728\u809d\u81df\u7684\u751f\u7406\u6046\u5b9a\u53ca\u809d\u764c\u767c\u751f\u7684\u904e\u7a0b\u6240\u626e\u6f14\u7684\u89d2\u8272\u3002\u5e0c\u671b\u6211\u5011\u5efa\u7acb\u7684\u57fa\u56e0\u5254\u9664\u9f20\u8cc7\u6e90\u5f97\u4ee5\u7528\u4f86\u7814\u7a76\u767c\u80b2\u7f3a\u9677\u6210\u56e0\u3001\u5668\u5b98\u751f\u7406\u6046\u5b9a\u53ca\u7d30\u80de\u764c\u5316\u4e4b\u91cd\u8981\u5206\u5b50\u8abf\u63a7\u3002<\/p>\n\n\n\n

Transgenic and knockout mice are powerful model systems for understanding embryonic development and disease progression. In the past, several knockout mouse models have been established in my laboratory. In combination with molecular and biochemical approaches, these mouse models are valuable tools for dissecting the mechanisms of the developmental defects (craniofacial and cardiovascular defects) and tumorigenesis (cancer initiation and the effects of diet or carcinogens on cancer promotion and progression).<\/p>\n\n\n\n

\u7814\u7a76\u8457\u4f5c<\/h1>\n\n\n\n

J. -W. Lin, Y. -M. Huang, Y. -Q. Chen, T. -Y. Chuang, T. -Y. Lan, Y. -W. Liu, H, -W, Pan, L. -R. You<\/u>, Y. -K. Wang, K. -H. Lin, A. Chiou, J. -C. Kuo. 2021. Dexamethasone accelerates muscle regeneration by modulating kinesin-1-mediated focal adhesion signals<\/span>. Cell Death Discov. 7:35.<\/em><\/p>\n\n\n\n

J. -R. Fan, L. -R. You<\/u>, W. -J. Wang, W. -S. Huang, C. -T. Chu, Y.-H. Chi, H. -C. Chen. 2020. Lamin A\u2010mediated nuclear lamina integrity is required for proper ciliogenesis.<\/span> EMBO Reports, e49680.<\/em><\/p>\n\n\n\n

C. L. Hochstetler, Y. Feng, M. Sacma, A. K. Davis, M. Rao, C. Y. Kuan, L. -R. You<\/u>, H. Geiger, Y. Zheng. 2019. KRasG12D<\/sup> expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals.<\/span> Exp Hematol. 79: 3-15.<\/em><\/p>\n\n\n\n

C. -H. Chan, C.-M. Chen, Y. -H. Wu Lee, and L. -R. You<\/u>. 2019. DNA damage, liver injury, and tumorigenesis: consequences of DDX3X loss. Mol. Cancer.<\/em><\/span> Res. 17:555-566.<\/em><\/p>\n\n\n\n

W. -L. Tu, L. -R. You<\/u>, A. -P. Tsou, and C. -M. Chen. 2018. Pten haplodeficiency accelerates liver tumor growth in miR-122a\u2013null mice via expansion of periportal hepatocyte-like cells.<\/span> Am J Pathol. 188: 2688-2702<\/em>. <\/p>\n\n\n\n

W-H Hsu, C-M Chen, L. -R. You<\/u>. 2017. COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring.<\/span> Sci Rep. 7:12386<\/em>.<\/p>\n\n\n\n

H. -K. Li, R. -T. Mai, H. -D. Huang, C. -H. Chou, Y. -A. Chang, Y. -W. Chang, L. -R. You<\/u>, C. -M. Chen and Y. -H. Wu Lee. 2016. DDX3 represses stemness by epigenetically modulating tumor-suppressive miRNAs in hepatocellular carcinoma.<\/span> Sci Rep. 6: 28637<\/em>.<\/p>\n\n\n\n

C. -Y. Chen, C. -H. Chan, C. -M. Chen, Y. -S. Tsai, T. -Y. Tsai, Y. -H. Wu Lee and L. -R. You<\/u>. 2016. Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.<\/span> Hum. Mol. Genet. 25: 2905-2922.<\/em><\/p>\n\n\n\n

C. -C. Liang, T. -L. Lu, Y. -R. Yu, L. -R. You<\/u>, C. -M. Chen. 2015. \u03b2-catenin activation drives thymoma initiation and progression in mice.<\/span> Oncotarget 6:13978-13993<\/em>.<\/p>\n\n\n\n

Y. -R. Yu, L. -R. You<\/u>, Y. -T. Yan, C. -M. Chen. 2014. Role of OVCA1\/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome.<\/span> Hum. Mol. Genet. 23:5579-5596<\/em>.<\/p>\n\n\n\n

C. -C. Liang, L. -R. You<\/u>, J. J. Y. Yen, N. -S. Liao, H. -F. Yang-Yen, C. -M. Chen. 2013. Thymic epithelial [beta]-catenin is required for adult thymic homeostasis and function.<\/span> Immunol Cell Biol 91: 511-523<\/em>.<\/p>\n\n\n\n

W. -H. Hsu, Y. -R. Yu, S. -H. Hsu, W. -C. Yu, Y. -H. Chu, Y. -J. Chen, C. -M. Chen and L. -R. You<\/u>. (2013) The Wilms\u2019 tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium.<\/span> Exp Cell Res 319: 1365-1381<\/em>.<\/p>\n\n\n\n

T. -L. Lu, Y. -F. Huang, L. -R. You<\/u>, N. -C. Chao, F. -Y. Su, J. -L. Chang, C. -M. Chen. (2013) Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice.<\/span> Am J Pathol. 182, 975-991<\/em>.<\/p>\n\n\n\n

W. -C. Chiu, J. -Y. Lin, T. -S. Lee, L. -R. You<\/u> and A. -N. Chiang. (2013) \u03b22<\/sub>-Glycoprotein I inhibits VEGF-induced endothelial cell growth and migration via suppressing phosphorylation of VEGFR2, ERK1\/2, and Akt<\/span>. Mol Cell Biochem. 372, 9-15<\/em>.<\/p>\n\n\n\n

F. -J. Lin*, L. -R. You<\/u>1<\/sup>, C. -T. Yu, W. -H. Hsu, M. -J. Tsai1<\/sup>1. (2012) Endocardial Cushion Morphogenesis and Coronary Vessel Development Require COUP-TFII.<\/span> Arterioscler Thromb Vasc Biol. 32, e135-146<\/em>. (* equal contribution; 1<\/sup>co-coresponding author)<\/p>\n\n\n\n

C. -M. Chen, T. -L. Lu, F. -Y. Su and L. -R. You<\/u>. (2012) Susceptibility of Epithelium to PTEN-Deficient Tumorigenesis<\/span>, Tumor Suppressor Genes, Yue Cheng (Ed.), ISBN: 978-953-307-879-3<\/em>, InTech, Available from: InTechOpen<\/a><\/p>\n\n\n\n

T. -C. Wei, H. -Y. Lin, C. -C. Lu, C. -M. Chen and L. -R. You<\/u>. (2011) Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions.<\/span> Gene Expr Patterns<\/em> 11, 384-394.<\/p>\n\n\n\n

H. -P. Huang, C. -L. Hong, C. -Y. Kao, S. -W. Lin, S. -R. Lin, H. -L. Wu, G. -Y. Shi, L. -R. You<\/u>, C. -L. Wu and I. -S. Yu. (2011) Gene targeting and expression analysis of mouse Tem1\/endosialin using a lacZ reporter.<\/span> Gene Expr Patterns 11, 316-326<\/em>.<\/p>\n\n\n\n

C. -M. Chen, H. -Y. Wang, L. -R. You<\/u>, R. -L. Shang and F. -C. Liu. (2010) Expression analysis of an evolutionary conserved metallophosphodiesterase gene, Mpped1, in the normal and \u03b2-catenin-deficient malformed dorsal telencephalon.<\/span> Dev. Dyn. 239, 1797-1806<\/em>.<\/p>\n\n\n\n

C. -C. Liang, L. -R. You<\/u>, J. -L. Chang, T. -F. Tsai and C. -M. Chen. (2009) Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs.<\/span> J Biomed. Sci. 16, 2<\/em>.<\/p>\n\n\n\n

T. -L. Lu., J. -L. Chang., C. -C. Liang, L. -R. You<\/u> and C. -M. Chen. (2007) Tumor Spectrum, Tumor Latency and Tumor Incidence of the Pten-Deficient Mice.<\/span> PLoSone, e1237<\/em>.<\/p>\n\n\n\n

L. -R. You<\/u>, N. Takamoto, C. -T. Yu, T. Tanaka, T. Kodama, F. J. DeMayo, S. Y. Tsai and M. -J. Tsai. (2005) Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia.<\/span> Proc Natl Acad Sci U S A. 102, 16351-16356<\/em>.<\/p>\n\n\n\n

M. -J. Tsai, L. -R. You<\/u>, SY. Tsai. (2005) Surprise in the Battle Field of Vein vs. Artery.<\/span> Organogenesis 2, 31-32<\/em>.<\/p>\n\n\n\n

M. -J. Tsai,L. -R. You<\/u>, F. -J. Lin and S. Y.Tsai. (2005) Essential role of COUP-TFII in vascular formation.<\/span> Kidney Int. 68, 1962-1963<\/em>.<\/p>\n\n\n\n

L. -R. You<\/u>, F. -J. Lin, C. T. Lee, F. J. DeMayo, M. -J. Tsai and S. Y. Tsai. (2005) Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.<\/span> Nature 435, 98-104<\/em>.<\/p>\n\n\n\n

N. Takamoto, L. -R. You<\/u>, K. Moses, C. Chiang, W. E. Zimmer. R. J. Schwartz, F. J. DeMayo, M. -J. Tsai and S. Y. Tsai. (2005) COUP-TFII is essential for radial and anterior-posterior patterning of the stomach.<\/span> Development 132, 2179-2189<\/em>.<\/p>\n\n\n\n

S. -Y. Chen, C. -F. Kao, C. -M. Chen, C. -M. Shih, M. -J. Hsu, C. -H. Chao, S, -H. Wang, L. -R. You<\/u> and Y. -H. Wu Lee. (2003) Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein.<\/span> J. Biol Chem. 278, 591-607<\/em>.<\/p>\n\n\n\n

T. J. Jaw, L. -R. You<\/u>, P. S. Konepfler, L. -C. Yao, C. -Y. Pai, C. -Y. Tang, , L. -P. Chang, Berthelsen, J., Kamps, M. P. and Y. H. Sun. (2000) Direct interaction of two homeoproteins, Homothorax and Extradenticle, is essential for EXD nuclear localization and function.<\/span> Mech. Dev. 91, 279-291<\/em>.<\/p>\n\n\n\n

L. -R. You<\/u>, C. -M. Chen, T. -S. Yeh, T, -Y. Tsai, R. -T. Mai and Y. -H. Wu Lee (1999) Hepatitis C virus core protein interacts with cellular putative RNA helicase.<\/span> J. Virol 73, 2841-2853<\/em>.<\/p>\n\n\n\n

L. -R. You<\/u>, C. -M. Chen and Y. -H. Wu Lee. (1999) The hepatitis C virus core protein modulates the NF-kB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor-alpha.<\/span> J. Virol 73, 1672-1681<\/em>.<\/p>\n\n\n\n

C. -M. Chen*, L. -R. You*<\/u>, L. -H. Hwang and Y. -H. Wu Lee. (1997) Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-\u03b2 receptor.<\/span> J. Virol 71, 9417-9426<\/em>. ( * equal contribution)<\/p>\n\n\n\n

R. Y. Wu, L. -R. You<\/u> and T. S. Soong. (1994) Nucleotide sequences of two circular single-stranded DNAs associated with banana bunchy top virus.<\/span> Phytopathology 84, 952-958<\/em>.<\/p>\n\n\n\n

C. G. Lin, L. -R. You<\/u> and S. J. Lo. (1993) Expression and stability of the hepatitis B pol protein in Escherichia coli.<\/span> J. Gestroentrology and Hepatology 8, S54-58<\/em>.<\/p>\n\n\n\n

S. J. Lo, L. -R. You<\/u> and Y. -H. Wu Lee. (1990) The hepatitis B virus X-C fusion protein is unlikely to be produced by the mechanism of ribosomal frameshifting.<\/span> Virology 178, 584-587<\/em>.<\/p>\n\n\n\n

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