{"id":553,"date":"2025-10-28T13:48:26","date_gmt":"2025-10-28T05:48:26","guid":{"rendered":"https:\/\/biochem.nycu.edu.tw\/%e9%bb%83%e4%bb%8b%e5%b6%b8\/"},"modified":"2025-10-28T15:23:50","modified_gmt":"2025-10-28T07:23:50","slug":"huang-jie-rong","status":"publish","type":"post","link":"https:\/\/biochem.nycu.edu.tw\/english\/faculty\/full-time\/huang-jie-rong\/","title":{"rendered":"Jie-rong Huang , PhD , Professor"},"content":{"rendered":"
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\u96fb\u8a71<\/mark>
886-2-2826-7258<\/h2>\n\n\n\n

Email<\/mark>
jierongh@nycu.edu.tw<\/a><\/h2>\n\n\n\n

\u500b\u4eba\u7db2\u7ad9<\/mark>
jierongh.lab.nycu.edu.tw<\/a><\/h2>\n\n\n\n

ORCiD<\/mark>
0000-0003-3674-2228<\/a><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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2007.03-2010.08<\/p>\n<\/div>\n\n\n\n

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\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u6559\u6388
\u570b\u7acb\u967d\u660e\u5927\u5b78 \u526f\u6559\u6388
\u570b\u7acb\u967d\u660e\u5927\u5b78 \u52a9\u7406\u6559\u6388
\u6cd5\u570b \u570b\u5bb6\u7814\u7a76\u4e2d\u5fc3 \u535a\u58eb\u5f8c\u7814\u7a76\u54e1
\u745e\u58eb \u5df4\u585e\u723e\u5927\u5b78 \u535a\u58eb\u5f8c\u7814\u7a76\u54e1<\/p>\n<\/div>\n<\/div>\n\n\n\n

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\u82f1\u570b\u528d\u6a4b\u5927\u5b78 \u535a\u58eb
\u570b\u7acb\u81fa\u7063\u5927\u5b78 \u5b78\u58eb<\/p>\n<\/div>\n<\/div>\n\n\n\n

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\u751f\u79d1\u9662 \u6559\u7814\u4eba\u54e1\u5b78\u8853\u5353\u8d8a\u734e\u52f5 (\u5169\u5e74)
\u751f\u79d1\u9662 \u6559\u7814\u4eba\u54e1\u5b78\u8853\u5353\u8d8a\u734e\u52f5 (\u5169\u5e74)
\u65e5\u672c\u5316\u5b78\u5b78\u6703 Lectureship Award
\u751f\u79d1\u9662 \u6559\u7814\u4eba\u54e1\u5b78\u8853\u5353\u8d8a\u734e\u52f5 (\u5169\u5e74)
\u967d\u660e\u5927\u5b78\u751f\u79d1\u9662\u6559\u5b78\u512a\u826f\u6559\u5e2b
\u967d\u660e\u5927\u5b78\u751f\u79d1\u9662\u6559\u7814\u4eba\u54e1\u5b78\u8853\u5353\u8d8a\u734e\u52f5 (\u5169\u5e74)
\u967d\u660e\u5927\u5b78\u512a\u826f\u5c0e\u5e2b
\u91ab\u5b78\u9662\u5b78\u751f\u7db2\u8def\u6559\u5b78\u8a55\u4f30\u512a\u826f\u6559\u5e2b
\u8ca1\u5718\u6cd5\u4eba\u6c88\u529b\u63da\u6559\u6388\u91ab\u5b78\u6559\u80b2\u734e\u5b78\u7d00\u5ff5\u57fa\u91d1\u6703\u7814\u7a76\u8207\u9032\u4fee\u734e\u52a9\u91d1
\u967d\u660e\u5927\u5b78\u826f\u5e2b\u76ca\u53cb\u5c0e\u5e2b
\u79d1\u6280\u90e8\u88dc\u52a9\u5927\u5c08\u6821\u9662\u5ef6\u652c\u7279\u6b8a\u512a\u79c0\u4eba\u624d (\u5169\u5e74)<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u6307\u5c0e\u5b78\u751f\u7372\u734e<\/h1>\n\n\n\n
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\u5468\u67cf\u541b \u6797\u715c\u7693 \u6797\u9038\u4e4b\u7684\u8ad6\u6587\u5728Cell Reports\u767c\u8868
\u9673\u70dc\u5112 \u69ae\u7372\u751f\u7269\u7269\u7406\u5e74\u6703\u58c1\u5831\u53e3\u982d\u7af6\u8cfd \u9280\u734e
\u6797\u54c1\u83e1\u3001\u5433\u51a0\u7def\u3001\u6797\u715c\u7693\u3001\u9ec3\u975c\u67d4\u7684\u8ad6\u6587\u5728ACS Chemical Neuroscience\u767c\u8868
\u5b6b\u6c38\u5bb8\u3001\u8b1d\u5b97\u502b\u3001\u6797\u4f73\u5100\u3001\u90b5\u742c\u6def\u3001\u6797\u715c\u7693\u7684\u8ad6\u6587\u5728Advanced Science\u767c\u8868
\u738b\u4e4b\u8377\u69ae\u7372\u300c\u570b\u79d1\u6703\u5927\u5c08\u751f\u7814\u7a76\u8a08\u756b\u300d
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\u6797\u54c1\u83e1\u69ae\u7372\u300c\u6559\u80b2\u90e8\u8207\u4e16\u754c\u767e\u5927\u5408\u4f5c\u8a2d\u7f6e\u734e\u5b78\u91d1\u300d<\/wbr>\u81f3\u6fb3\u6d32\u96ea\u68a8\u5927\u5b78\u653b\u8b80\u535a\u58eb
\u5468\u67cf\u541b\u7372\u751f\u91ab\u5e74\u6703\u58c1\u5831\u7279\u512a\u734e\u00a0
\u6797\u715c\u7693\u3001\u8b1d\u5b97\u502b\u7372\u9080\u81f3\u53f0\u65e5NMR\u4ea4\u6d41\u7814\u8a0e\u6703\u767c\u8868\u77ed\u8b1b\u00a0\u00a0
\u78a9\u58eb\u751f\u7562\u696d\u751f\u4f55\u739f\u9716\u69ae\u7372\u65b9\u8ce2\u9f4a\u5148\u751fBioICT\u8ad6\u6587\u734e\u78a9\u58eb\u8ad6\u6587\u982d\u7b49\u734e
\u535a\u58eb\u751f\u6797\u715c\u7693\u7372\u9078\u70ba\u570b\u969b\u91a3\u79d1\u5b78\u5e74\u6703-\u534a\u4e73\u7cd6\u5b50\u6703\u77ed\u6f14\u8b1b\u8005
\u535a\u58eb\u751f\u5b6b\u6c38\u5bb8\u7372\u9078\u70ba\u570b\u969b\u78c1\u5171\u632f\u5e74\u6703\u77ed\u6f14\u8b1b\u8005
\u78a9\u58eb\u751f\u4f55\u739f\u9716\u7684\u8ad6\u6587\u5728Protein Science\u767c\u8868\u00a0
\u78a9\u58eb\u751f\u738b\u88d5\u5148\u69ae\u7372\u967d\u660e\u4ea4\u5927\u57fa\u79d1\u6240\u58c1\u5831\u6bd4\u8cfd\u4f73\u4f5c\u00a0
\u535a\u58eb\u751f\u5b6b\u6c38\u5bb8\u69ae\u7372\u7b2c27\u5c46\u751f\u7269\u7269\u7406\u5e74\u6703\u53e3\u982d\u8ad6\u6587\u7af6\u8b1b\u7b2c\u4e09\u540d\u00a0
\u52a9\u7406\u6797\u715c\u7693\u69ae\u7372TIGP Rising Star Fellowship (4.6\u842c\/\u6708;\u4e09\u5e74)
\u78a9\u58eb\u751f\u4f55\u739f\u9716\u7684\u7814\u7a76\u6210\u679c\u5728 Protein Science \u767c\u8868
\u78a9\u58eb\u751f\u90b1\u8a69\u60e0\u7684\u7814\u7a76\u6210\u679c\u5728 Communications Biology \u767c\u8868
\u535a\u58eb\u751f\u5468\u67cf\u541b \u69ae\u7372\u53f0\u7063\u751f\u5316\u5206\u751f\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587\u6bd4\u8cfd \u7279\u512a
\u78a9\u58eb\u751f\u90b1\u8a69\u60e0 \u7372\u8ad6\u6587\u512a\u826f\u9662\u9577\u734e
\u78a9\u73ed\u7562\u696d\u751f\u6c5f\u5b9b\u82b9 \u7372\u5f97\u745e\u58eb\u8607\u9ece\u58eb\u5927\u5b78\u5168\u984d\u734e\u5b78\u91d1\u653b\u8b80\u535a\u58eb\u5b78\u4f4d
\u78a9\u58eb\u751f\u90b1\u8a69\u60e0 \u751f\u7269\u91ab\u5b78\u6838\u78c1\u5171\u632f\u7814\u8a0e\u6703\u53e3\u982d\u8ad6\u6587\u7af6\u8cfd \u4f73\u4f5c
\u78a9\u58eb\u751f\u5b6b\u6c38\u5bb8 \u7372\u751f\u79d1\u9662\u734e\u5b78\u91d1(20k)\u8207TIGP Rising Star fellowship (40k\/month; 3 year)
\u78a9\u58eb\u751f\u90b1\u6021\u840d\u3001\u5b6b\u6c38\u5bb8\u3001\u90b1\u5f97\u5bb8\u3001\u6797\u715c\u7693\u7684\u7814\u7a76\u6210\u679c\u5728Nature Communications\u767c\u8868
\u535a\u58eb\u751f\u9673\u91c7\u699b\u7684\u7814\u7a76\u6210\u679c\u5728Int J Mol Sciences \u767c\u8868
\u78a9\u58eb\u751f\u5b6b\u6c38\u5bb8 \u751f\u5316\u6240\u5c39\u73e3\u82e5\u8ad6\u6587\u6bd4\u8cfd\u7b2c\u4e09\u540d
\u78a9\u58eb\u751f\u90b1\u6021\u840d \u7372\u6559\u80b2\u90e8\u88dc\u52a9\u81f3\u97d3\u570b\u4e2d\u592e\u5927\u5b78\u64d4\u4efb\u4ea4\u63db\u5b78\u751f
\u78a9\u58eb\u751f\u90b1\u6021\u840d \u7b2c24\u5c46\u751f\u7269\u7269\u7406\u5e74\u6703\u53e3\u982d\u8ad6\u6587\u7af6\u8b1b\u7b2c\u4e09\u540d(JBC Award)
\u78a9\u58eb\u751f\u6c5f\u5b9b\u82b9 \u7b2c23\u5c46\u751f\u7269\u7269\u7406\u5e74\u6703\u53e3\u982d\u8ad6\u6587\u7af6\u8b1b\u7b2c\u4e8c\u540d
\u78a9\u58eb\u751f\u6c5f\u5b9b\u82b9 \u751f\u5316\u6240\u5c39\u73e3\u82e5\u8ad6\u6587\u6bd4\u8cfd\u7b2c\u4e00\u540d\uff0c\u4ee3\u8868\u6240\u53c3\u52a0\u5168\u6821\u6bd4\u8cfd
\u5c08\u984c\u751f\u5b6b\u6c38\u5bb8 \u8003\u53d6\u967d\u660e\u5927\u5b78\u751f\u5316\u6240\u699c\u9996
\u78a9\u58eb\u751f\u674e\u660a\u5112\u3001\u6c5f\u5b9b\u82b9\uff0c\u52a9\u7406\u5468\u67cf\u541b\u7684\u7814\u7a76\u6210\u679c\u5728JBC\u767c\u8868\uff01
\u78a9\u58eb\u751f\u90b1\u5f97\u5bb8 \u7372\u5f97\u53f0\u65e5\u751f\u7269\u91ab\u5b78\u78c1\u5171\u632f\u7814\u8a0e\u6703\u6700\u4f73\u58c1\u5831\u734e
\u78a9\u58eb\u751f\u674e\u660a\u5112\u3001\u535a\u58eb\u751f\u9673\u91c7\u699b\u7684\u7814\u7a76\u6210\u679c\u5728BBA\u767c\u8868\uff01
\u78a9\u58eb\u751f\u6797\u715c\u7693\u3001\u90b1\u5f97\u5bb8\u3001\u52a9\u7406\u5f35\u96ef\u6db5\u7684\u7814\u7a76\u6210\u679c\u5728JBC\u767c\u8868\uff01
\u535a\u58eb\u751f\u9673\u91c7\u699b\u3001\u52a9\u7406\u856d\u81f3\u502b\u65bc\u7684\u7814\u7a76\u6210\u679c\u5728 PPL \u767c\u8868
\u535a\u58eb\u751f\u9673\u91c7\u699b \u7372\u5f97\u570b\u969b\u751f\u7269\u78c1\u5171\u632f\u7814\u8a0e\u6703(Kyoto) Travel Award
\u535a\u58eb\u751f\u9673\u91c7\u699b \u7372\u5f97\u53f0\u7063\u78c1\u5171\u632f\u5e74\u6703\u512a\u826f\u58c1\u5831\u734e<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u7814\u7a76\u65b9\u5411<\/h1>\n\n\n\n

\u5728\u4e00\u9846\u7d30\u80de\u5167\uff0c\u6709\u6210\u5343\u4e0a\u842c\u7684\u751f\u7269\u5316\u5b78\u53cd\u61c9\u540c\u6642\u5728\u767c\u751f\u8457\u3002\u7136\u800c\uff0c\u9019\u4e9b\u53c3\u8207\u53cd\u61c9\u7684\u751f\u7269\u5206\u5b50\uff0c\u5982\u86cb\u767d\u8cea\u3001\u6838\u9178\u7b49\uff0c\u5b83\u5011\u600e\u9ebc\u300c\u77e5\u9053\u300d\u81ea\u5df1\u8a72\u5728\u4f55\u6642\u3001\u4f55\u8655\u53c3\u8207\u90a3\u4e9b\u53cd\u61c9\uff1f\u9019\u662f\u6211\u5011\u5be6\u9a57\u5ba4\u6700\u6709\u8208\u8da3\u4e86\u89e3\u7684\u554f\u984c\u3002
\u771f\u6838\u7d30\u80de\u5167\u6709\u4e00\u534a\u4ee5\u4e0a\u7684\u86cb\u767d\u8cea\u5e36\u6709\u7121\u7279\u5b9a\u4e09\u7dad\u7d50\u69cb\u7684\u300c\u56fa\u6709\u7121\u5e8f\u300d\u5340\u6bb5(intrinsically disordered domains; IDPs or IDRs)\uff0c\u9019\u4e9b\u7121\u5e8f\u5340\u6bb5\u7684\u7279\u6027\uff0c\u5f88\u53ef\u80fd\u5c31\u6c7a\u5b9a\u4e86\u8a72\u86cb\u767d\u8cea\u8a72\u5728\u4f55\u6642\u4f55\u8655\u53c3\u8207\u53cd\u61c9\u3002\u8fd1\u4f86\u6709\u4e9b\u7814\u7a76\u5df2\u767c\u73fe\u8a31\u591a\u9019\u985e\u86cb\u767d\u8cea\u53ef\u4ee5\u5229\u7528\u5916\u754c\u74b0\u5883(\u5982\u9178\u9e7c\u5ea6\u3001\u6eab\u5ea6)\u7684\u6539\u8b8a(\u300c\u4f55\u6642\u300d)\u9032\u884c\u6db2-\u6db2\u76f8\u5206\u96e2(liquid-liquid phase separation; LLPS)\uff0c\u85c9\u4ee5\u9054\u5230\u5728\u7d30\u80de\u5167\u5c40\u90e8\u7684\u6fc3\u5ea6\u63d0\u9ad8\uff0c\u800c\u5728\u7279\u5b9a\u5730\u9ede\u767c\u751f\u53cd\u61c9(\u300c\u4f55\u8655\u300d)\u3002\u9664\u4e86\u591a\u7a2e\u529f\u80fd\u5916\uff0c\u9019\u4e9b\u5340\u6bb5\u7684\u8b8a\u7570\u4e5f\u548c\u591a\u7a2e\u75be\u75c5\u6709\u95dc\uff0c\u800c\u6211\u5011\u5be6\u9a57\u5ba4\u6709\u8208\u8da3\u7684\u4e3b\u984c\u7686\u662f\u70ba\u4e86\u89e3IDP\/LLPS\u7684\u7279\u6027\u53ca\u5176\u751f\u7269\u529f\u80fd\u8207\u75be\u75c5\u9593\u7684\u95dc\u4fc2\u3002\u76ee\u524d\u8457\u91cd\u7684\u4e3b\u984c\u53ef\u5206\u70ba\u4e0b\u5217\u5e7e\u9805\uff1a<\/p>\n\n\n\n

    \n
  1. \u57fa\u56e0\u8abf\u63a7 : \u6211\u5011\u76ee\u524d\u7814\u7a76\u591a\u500b\u5e36\u6709IDR\u7684RNA binding proteins\u548ctranscription factors\u3002\u6211\u5011\u5e0c\u671b\u4e86\u89e3\u9019\u4e9bIDR\u662f\u5982\u4f55\u8abf\u63a7\u5b83\u5011\u76f8\u95dc\u7684\u57fa\u56e0\u53ca\u529f\u80fd\u7684\u3002<\/li>\n\n\n\n
  2. \u795e\u7d93\u9000\u5316\u6027\u75be\u75c5 : TDP-43 \u9019\u500b\u86cb\u767d\u8cea\u7121\u5e8f\u5340\u6bb5\u7684\u4e0d\u6b63\u5e38\u5806\u96c6\u662f\u6f38\u51cd\u4eba\u75c7\u548c\u4e00\u7a2e\u5931\u667a\u75c7\u7684\u4e3b\u8981\u539f\u56e0\u3002\u9019\u500b\u7121\u5e8f\u5340\u6bb5\u662f\u600e\u9ebc\u5806\u96c6\u7684\uff1f\u70ba\u4ec0\u9ebc\u81ea\u7136\u8981\u6f14\u5316\u51fa\u6703\u4e0d\u6b63\u5e38\u5806\u96c6\u7684\u5340\u6bb5\uff1f\u9019\u500b\u5340\u6bb5\u662f\u4e0d\u662f\u9084\u6709\u5176\u5b83\u529f\u80fd\uff1f\u9019\u662f\u6211\u5011\u6709\u8208\u8da3\u7684\u554f\u984c\u3002<\/li>\n\n\n\n
  3. \u764c\u75c7 : Galectin-3 \u662f\u4eba\u9ad4\u5167\u552f\u4e00\u4e00\u7a2e\u5e36\u6709\u7121\u5e8f\u5340\u6bb5\u7684\u534a\u4e73\u7cd6\u51dd\u96c6\u7d20\u3002\u5b83\u5728\u767c\u708e\u53ca\u4e00\u4e9b\u764c\u7d30\u80de\u5167\u6703\u5927\u91cf\u7522\u751f\uff0c\u4f46\u5b83\u7522\u751f\u7684\u6a5f\u5236\u548c\u764c\u75c7\u4e4b\u9593\u7684\u95dc\u4fc2\u4e26\u4e0d\u6e05\u695a\uff0c\u9019\u4e5f\u662f\u6211\u5011\u76ee\u524d\u7814\u7a76\u7684\u65b9\u5411\u4e4b\u4e00\u3002<\/li>\n\n\n\n
  4. \u85e5\u7269\u8a2d\u8a08 : \u73fe\u5728\u4ee5\u86cb\u767d\u8cea\u7d50\u69cb\u70ba\u57fa\u790e\u7684\u85e5\u7269\u958b\u767c(structure-based drug design)\u90fd\u662f\u4ee5\u6709\u4e09\u7d1a\u7d50\u69cb\u7684\u6d3b\u6027\u4f4d\u6216\u8abf\u7bc0\u4f4d\u505a\u8a2d\u8a08\uff0c\u9bae\u5c11\u4ee5\u7121\u5e8f\u5340\u6bb5\u4f5c\u70ba\u76ee\u6a19\u3002\u4ee5\u4e0a(1)-(3)\u63d0\u5230\u7684\u529f\u80fd\u8207\u75be\u75c5\uff0c\u6211\u5011\u767c\u73fe\u90fd\u548cIDR\u6240\u8abf\u63a7\u7684LLPS\u6709\u95dc\u3002\u56e0\u6b64\uff0c\u6211\u5011\u6703\u91dd\u5c0d\u6703\u5f62\u6210\u6db2-\u6db2\u76f8\u5206\u96e2\u7684\u7121\u5e8f\u86cb\u767d\u8cea\u70ba\u76ee\u6a19\uff0c\u91dd\u5c0d\u5b83\u5011\u51dd\u96c6\u4f5c\u7528\u7684\u6a5f\u5236\uff0c\u4f86\u627e\u51fa\u9069\u5408\u8abf\u63a7\u9019\u4e9b\u6a5f\u5236\u7684\u85e5\u7269\u3002<\/li>\n\n\n\n
  5. \u4eba\u5de5\u667a\u6167\u548c\u751f\u7269\u8cc7\u8a0a\u5b78\uff1a\u6211\u5011\u5229\u7528\u8cc7\u6599\u5eab\u4e2d\u7684\u540c\u6e90IDR\u4f86\u8a13\u7df4\u6a21\u578b\uff0c\u8b93AI\u53bb\u627e\u51faIDR\u4e2d\u53ef\u80fd\u529f\u80fd\u5f88\u91cd\u8981\u7684\u80fa\u57fa\u9178\u3002\u6211\u5011\u4e5f\u5206\u6790\u591a\u7a2e\u86cb\u767d\u8cea\u5e8f\u5217\u8cc7\u6599\u5eab\uff0c\u5e0c\u671b\u4e86\u89e3IDR\u662f\u5982\u4f55\u6f14\u5316\u51fa\u4f86\u7684\u3002<\/li>\n<\/ol>\n\n\n\n

    Advanced Science<\/em> (2024) \u76f8\u95dc\u5831\u5c0e<\/strong><\/h1>\n\n\n\n
    \n
    \n

    \u967d\u660e\u4ea4\u5927\u5b98\u7db2<\/a>
    \u967d\u660e\u4ea4\u5927\u5b98\u7db2(English)<\/a>
    \u4e2d\u592e\u793e<\/a>
    \u81ea\u7531\u6642\u5831<\/a>
    \u806f\u5408\u5831<\/a>
    \u4e2d\u570b\u6642\u5831<\/a>
    \u570b\u79d1\u6703 \u5316\u5b78\u96fb\u5b50\u5831<\/a><\/h2>\n<\/div>\n<\/div>\n\n\n\n


    <\/p>\n\n\n\n

    Nature Communications<\/em> (2020) \u76f8\u95dc\u5831\u5c0e<\/h1>\n\n\n\n
    \n
    \n

    \u967d\u660e\u5927\u5b78\u5c08\u8a2a(Youtube)<\/a>
    \u967d\u660e\u5927\u5b78\u5b98\u7db2(\u820a\u7db2\u9801\u7559\u5b58)<\/a>
    \u74b0\u7403\u751f\u6280<\/a>
    \u570b\u7acb\u6559\u80b2\u5ee3\u64ad\u96fb\u53f0<\/a><\/h2>\n<\/div>\n<\/div>\n\n\n\n

    <\/p>\n\n\n\n

    2024 \u8afe\u8c9d\u723e\u5316\u5b78\u734e\u4ee5\u76f8\u95dc\u9818\u57df\u5c08\u5bb6\u8eab\u4efd\u53d7\u8a2a<\/h1>\n\n\n\n
    \n
    \n

    \u95dc\u9375\u5c08\u8a2a<\/a>
    \u53f0\u7063\u79d1\u6280\u5a92\u9ad4\u4e2d\u5fc3<\/a><\/h2>\n<\/div>\n<\/div>\n\n\n\n

    <\/p>\n\n\n\n

    \u7814\u7a76\u8457\u4f5c<\/h1>\n\n\n\n

    Chou PC, Lin YH, Lin IH, Lin TY, Huang YC, Hong SR, Chang TJ, Lin Y, Yang TT, Lin YC, Huang JR*<\/u>, Wang WC*. Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis<\/mark> (2025) Cell Reports <\/em><\/p>\n\n\n\n

    Huang JR*<\/u>Microexon in action: How tiny fragments in a protein tune function, drive disease<\/mark> (2025) Molecular Cell 85(2):202-204 (invited contribution) <\/em><\/p>\n\n\n\n

    Lin PH, Wu GW, Lin YH, Huang JR, Jeng US, Liu WM*, and Huang JR*<\/u>  TDP-43 amyloid fibril formation via phase separation-related and -unrelated pathways<\/mark> (2024) ACS Chem Neurosci.<\/em><\/p>\n\n\n\n

    Sun YC, Hsieh TL, Lin CY, Shao WY, Lin YH,and Huang JR*<\/u>. A few charged residues in galectin-3\u2019s folded and disordered regions regulate phase separation<\/mark> (2024) Adv Sci 2402570<\/em>.<\/p>\n\n\n\n

    Siew JJ, Chen HM, Chiu FL, Lee CW, Chang YM, Chen HL, Nguyen TNA, Liao HT, Liu M, Hagar HT, Sun YC, Lai HL, Kuo MH, Blum D, Buee L, Jin LW, Chen SY, Ko TM, Huang JR<\/u>, Kuo HC, Liu FT, and Chern Y. Galectin-3 aggravates microglial activation and tau transmission in tauopathy<\/mark> (2023) J Clin Invest 134(2):e165523.<\/em><\/p>\n\n\n\n

    Ho WL, Huang HC, and Huang JR*<\/u>. IFF: Identifying key residues in intrinsically disordered regions of proteins using machine learning<\/mark> (2023) Prot Sci 3;32:e4739<\/em> <\/p>\n\n\n\n

    Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Jie-rong Huang<\/u>, Chen RH. PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly<\/mark> (2023) Mol Cell<\/em> <\/p>\n\n\n\n

    Chiu SH, Ho WL, Sun YC, Kuo JC, and Huang JR*<\/u>. Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs. <\/mark>(2022) Comm. Biol. 5:400<\/em><\/p>\n\n\n\n

    Ho WL and Huang JR*<\/u>. The return of the rings: Evolutionary convergence of aromatic residues in the intrinsically disordered regions of RNA-binding proteins for liquid-liquid phase separation.<\/mark> (2022) Prot Sci 31:e4317<\/em><\/p>\n\n\n\n

    Chiang WC, Lee MH, Chen TC, and Huang JR*<\/u>. Interactions between the Intrinsically Disordered Regions of hnRNP-A2 and TDP-43 Accelerate TDP-43\u2032s Conformational Transition.<\/mark> (2020) Int J Mol Sci. 21(16), 5930<\/em><\/p>\n\n\n\n

    Chiu YP, Sun YC, Qiu DC, Lin YH, Chen YQ, Kuo JC, and Huang JR*<\/u>. Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3.<\/span> (2020) Nat Comm 11:1229<\/em><\/p>\n\n\n\n

    Chen TC and Huang JR*<\/u>. Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins.<\/span> (2020) Int J Mol Sci. 21(7). pii: E2289<\/em><\/p>\n\n\n\n

    Li HR, Chiang WC, Chou PC, Wang WJ, Huang JR*<\/u>. TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues. <\/span>(2018) J Biol Chem. 293(16):6090-6098<\/em><\/p>\n\n\n\n

    Li HR, Chen TC, Hsiao CL, Shi L, Chou CY, Huang JR*<\/u>. The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43.<\/span> (2018) BBA-Proteins and Proteomics. 1866:214-223<\/em><\/p>\n\n\n\n

    Lin YH, Qiu DC, Chang WH, Yeh YQ, Jeng US, Liu FT, Huang JR*<\/u>. The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions.<\/span> (2017) J Biol Chem. 292(43) 17845\u201317856<\/em><\/p>\n\n\n\n

    Chen TC, Hsiao CL, Huang SJ, Huang JR*<\/u>. The nearest-neighbor effect on random-coil NMR chemical shifts demonstrated using a low-complexity amino-acid sequence. <\/span>(2016) Protein Pept Lett. 23(11):967-975<\/em><\/p>\n\n\n\n

    Delaforge E, Milles S, Huang JR<\/u>, Bouvier D, Jensen MR, Sattler M, Hart JD, Blackledge M. Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions.<\/span> (2016) Front. Mol. Biosci. 3:54<\/em><\/p>\n\n\n\n

    Aznauryan M, Delgado L, Soranno A, Nettels D, Huang JR<\/u>, Labhardt AM, Grzesiek S, Schuler B. Comprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS.<\/span> (2016) PNAS. 113(37):E5389-98<\/em><\/p>\n\n\n\n

    Huang JR<\/u>, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M, Blackledge M. Transient electrostatic interactions dominate the conformational equilibrium sampled by multi-domain splicing factor U2AF65: A combined NMR and SAXS study.<\/span> (2014) J Am Chem Soc. 136(19):7068-76<\/em><\/p>\n\n\n\n

    Jensen MR, Zweckstetter M, Huang JR<\/u>, Blackledge M. Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy.<\/span> (2014) Chem Rev. 114(13):6632-60<\/em>
    Before 2013<\/p>\n\n\n\n

    Huang J-R<\/u>, Ozenne V, Jensen MR, and Blackledge M. Direct prediction of NMR residual dipolar couplings from the primary sequence of unfolded proteins.<\/span> (2013) Angew Chem Int Ed. 52(2):687-690 (Cover Issue)<\/em><\/p>\n\n\n\n

    Huang J-R<\/u>, Gentner M, Vajpai N, Grzesiek S, and Blackledge M. Residual dipolar couplings measured in unfolded proteins are sensitive to amino- acid specific geometries as well as local conformational sampling.<\/span> (2012) Biochem Soc T. 40(5):989-94<\/em><\/p>\n\n\n\n

    Ozenne V, Schneider R, Yao M, Huang J-R<\/u>, Salmon L, Zweckstetter M, Jensen MR and Blackledge M. Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution.<\/span> <\/em>(2012) J Am Chem Soc. 134(36):15138-48<\/em><\/p>\n\n\n\n

    Ozenne V, Bauer F, Salmon L, Huang J-R<\/u>, Jensen MR, Segard S, Bernado P, Charavay C, and Blackledge M. Flexible-meccano: A tool for the generation of explicit ensemble description of intrinsically dis- ordered proteins and their associated experimental observables.<\/span> (2012) Bioinfomatics. 28(11):1463-70<\/em><\/p>\n\n\n\n

    Silvers R, Sziegat F, Tachibana H, Segawa S, Whittaker S, Gunther U, Gabel F, Huang J-R<\/u>, Blackledge M, Wirmer J, and Schwalbe H. Modulation of structure and dynamics by disulfide bond formation in unfolded states.<\/span> (2012) J Am Chem Soc. 134(15):6846-54<\/em><\/p>\n\n\n\n

    Huang J-R<\/u>, Gabel F, Jensen MR, Grzesiek S, and Blackledge M. Sequencespecific mapping of the interaction between urea and unfolded ubiquitin from ensemble analysis of NMR and small angle scattering data.<\/span> (2012) J Am Chem Soc. 134(9):4429-36<\/em><\/p>\n\n\n\n

    Schneider R, Huang J-R<\/u>, Yao M, Communie G, Ozenne V, Mollica L, Salmon L, Jensen MR, and Blackledge M. Towards a robust descrip- tion of intrinsic protein disorder using nuclear magnetic resonance spec- troscopy.<\/span> (2012) Mol Biosyst. 8(1):58-68<\/em><\/p>\n\n\n\n

    Vajpai N, Gentner M, Huang J-R<\/u>, Blackledge M, and Grzesiek S. Sidechain \u03c71 conformations in urea-denatured ubiquitin and protein G from 3J coupling constants and residual dipolar couplings.<\/span> (2010) J Am Chem Soc. 132(9):3196-203<\/em><\/p>\n\n\n\n

    Huang J-R<\/u> and Grzesiek S. Ensemble calculations of unstructured proteins constrained by RDC and PRE data: a case study of urea-denatured ubiquitin.<\/span> (2010) J Am Chem Soc. 132(2):694-705<\/em><\/p>\n\n\n\n

    Haussinger D, Huang J-R<\/u>, and Grzesiek S. DOTA-M8\u2013an extremely rigid, high-affinity lanthanide chelating tag for PCS NMR.<\/span> (2009) J Am Chem Soc. 131(41):14761-7<\/em><\/p>\n\n\n\n

    Huang J-R<\/u>, Hsu S-TD, Christodoulou J, and Jackson SE. The extremely slow-exchanging core and acid-denatured state of Green Fluorescent Pro- tein.<\/span> (2008) HFSP Journal. 2(6):378-87<\/em><\/p>\n\n\n\n

    Huang J-R<\/u>, Craggs TD, Christodoulou J, and Jackson SE. Stable intermediate states and high energy barriers in the unfolding of GFP.<\/span> (2007) J Mol Biol. 370(2):356-71<\/em><\/p>\n\n\n\n

    Jackson SE, Craggs TD, Huang J-R. Understanding the folding of GFP using biophysical techniques.<\/span> (2006) Expert Rev Proteomics. 3(5):545-59<\/em><\/p>","protected":false},"excerpt":{"rendered":"

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