{"id":554,"date":"2025-10-28T09:05:22","date_gmt":"2025-10-28T01:05:22","guid":{"rendered":"https:\/\/biochem.nycu.edu.tw\/%e9%99%b3%e5%a8%81%e5%84%80\/"},"modified":"2026-03-06T11:19:39","modified_gmt":"2026-03-06T03:19:39","slug":"chen-wei-yi","status":"publish","type":"post","link":"https:\/\/biochem.nycu.edu.tw\/english\/faculty\/full-time\/chen-wei-yi\/","title":{"rendered":"Wei-Yi Chen , PhD , Professor"},"content":{"rendered":"
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\u751f\u7269\u91ab\u5b78\u5927\u6a13 \u4e03\u6a13 R711 \u5ba4<\/h2>\n\n\n\n

\u96fb\u8a71<\/mark>
886-2-2826-7328<\/h2>\n\n\n\n

Email<\/mark>
chenwy@nycu.edu.tw<\/a> <\/h2>\n\n\n\n

ORCiD<\/mark>
0000-0002-0661-6899<\/a><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u91ab\u5b78\u9662 \u5b78\u751f\u7db2\u8def\u6559\u5b78\u8a55\u4f30\u512a\u826f\u6559\u5e2b
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\u6307\u5c0e\u5b78\u751f\u7372\u734e<\/h1>\n\n\n\n
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2024
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\u91ab\u5b78\u7cfb\u5c08\u984c\u751f \u5f90\u6069\u6770\u7372\u5f97\u7f8e\u570b\u65af\u9686\u51f1\u7279\u7433\u91ab\u5b78\u4e2d\u5fc3\u6691\u671f\u7814\u4fee
\u78a9\u58eb\u751f\u9ec3\u570b\u8aa0 \u69ae\u7372\u967d\u660e\u5927\u5b78\u751f\u5316\u6240\u5c39\u73e3\u82e5\u8ad6\u6587\u6bd4\u8cfd\u7b2c\u4e09\u540d<\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/h2>\n\n\n\n

\u7814\u7a76\u65b9\u5411<\/h1>\n\n\n\n

Antibody producing B cells arise from hematopoietic stem cells through a series of developmental steps that involve a hierarchical transcription factor network. Whereas much is known about their direct genetic targets, little is known about their actual mechanism of action through interactions with various coactivators that act on chromatin structure or on the general transcription machinery. In addition, genetic mutations of the involved transcription factors result in loss-of-function or gain-of-function frequently lead to B cell deficiency or malignancy.<\/p>\n\n\n\n

Our goal is to uncover the mechanisms by which transcriptional activators\/coactivators (including various histone modifiers\/remodelers) control the development and leukemogenesis of B-lymphocytes, as well as searching therapeutic targets\/approaches for B-cells associated leukemia\/lymphoma.
On-going studies will employ various state-of-the-art biomedical technologies that include:<\/p>\n\n\n\n

    \n
  1. biochemically isolating recombinant proteins\/ protein complexes from bacteria\/insect\/mammalian cell cultures for cell-free assays<\/li>\n\n\n\n
  2. genome-widely profiling (ChIP-seq and RNA-seq) the transcription-related factors (DNA-binding proteins and transcriptional coactivators) and corresponding histone modifications in normal or malignant cells<\/li>\n\n\n\n
  3. developing the peptidomimetics for potential therapeutic to leukemia\/lymphoma treatment<\/li>\n<\/ol>\n\n\n\n

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    \u76ee\u524d\uff0c\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u4e3b\u984c\u4e4b\u4e00\u662f\u60f3\u77ad\u89e3\u8f49\u9304\u56e0\u5b50 E2A \u878d\u5408\u86cb\u767d\u9020\u6210 B \u7d30\u80de\u816b\u7624\u7684\u5206\u5b50\u6a5f\u8f49\uff0c\u4ee5\u53ca\u6240\u8abf\u63a7\u7684\u57fa\u56e0\u7d44\u3002 \u6211\u5011\u767c\u73fe E2A \u878d\u5408\u86cb\u767d\u80fd\u626e\u6f14\u4e00\u822c\u8f49\u9304\u8f14\u56e0\u5b50\u7684\u529f\u80fd\uff0c\u4fc3\u9032\u53e6\u4e00\u500b\u8f49\u9304\u56e0\u5b50 RUNX1 \u7684\u6d3b\u6027\u800c\u9020\u6210\u8840\u7403\u5e79\u7d30\u80de\u7121\u6cd5\u5206\u5316\uff0c\u9019\u500b\u767c\u73fe\u5728\u672a\u4f86\u80fd\u63d0\u4f9b\u6cbb\u7642B\u7d30\u80de\u816b\u7624\u7684\u7cbe\u6e96\u91ab\u7642\u7b56\u7565\u3002 \u6b64\u5916\uff0c\u6211\u5011\u7684\u53e6\u4e00\u500b\u7814\u7a76\u65b9\u5411\u662f\u57fa\u56e0\u8f49\u9304\u4f5c\u7528\u5982\u4f55\u8abf\u63a7\u80ba\u764c\u7d30\u80de\u7684\u8f49\u79fb\u3002\u5229\u7528\u9ad8\u901a\u91cf\u5168\u57fa\u56e0\u9ad4DNA \u5b9a\u5e8f\u7684\u5206\u6790\u6cd5 (ChIP-seq \u53ca RNA-seq)\uff0c\u6211\u5011\u767c\u73fe\u5728\u9ad8\u8f49\u79fb\u80fd\u529b\u7684\u80ba\u764c\u7d30\u80de\u6703\u5927\u91cf\u8868\u73fe CDCP1 \u819c\u86cb\u767d\uff0cCDCP1 \u8abf\u63a7\u764c\u7d30\u80de\u8f49\u79fb\u5df2\u7d93\u5831\u5c0e\u65bc\u8a31\u591a\u6587\u737b\u4e2d\uff0c\u4f46 CDCP1 \u70ba\u4f55\u6703\u5728\u764c\u7d30\u80de\u4e2d\u5927\u91cf\u8868\u73fe\u5247\u4e0d\u6e05\u695a\u3002\u900f\u904e\u8868\u89c0\u57fa\u56e0\u9ad4\u7684\u5206\u6790\uff0c\u6211\u5011\u767c \u73fe CDCP1 \u7684\u57fa\u56e0\u5340\u6bb5\u53ea\u6709\u5728\u9ad8\u8f49\u79fb\u7684\u7d30\u80de\u4e2d\u6703\u5f62\u6210\u8d85\u7d1a\u589e\u5f37\u5b50\uff0c\u77ad\u89e3CDCP1\u8d85\u7d1a\u589e\u5f37\u5b50\u7684\u5f62\u6210\u6a5f\u8f49\u5c07\u6709\u52a9\u65bc\u63d0\u4f9b\u672a\u4f86\u7cbe\u6e96\u91ab\u7642\u7684\u7b56\u7565\u3002<\/p>\n\n\n\n

    \u7814\u7a76\u6210\u679c\u76f8\u95dc\u65b0\u805e\u5831\u5c0e<\/strong><\/h1>\n\n\n\n


    \u70ba\u4ec0\u9ebc\u6703\u6709\u8840\u764c\uff1f\u539f\u4f86\u662f\u8840\u7403\u5e79\u7d30\u80de\u4e3b\u5bb0\u56e0\u5b50\u88ab\u7d81\u67b6\u633e\u6301\u4e86<\/a>\u2500YouTube

    \u8840\u764c\u95dc\u9375\u539f\u56e0\u627e\u5230\u4e86\uff01\u967d\u660e\u5718\u968a\uff1a\u6291\u5236\u7279\u5b9a\u86cb\u767d\u6709\u671b\u6839\u6cbb\u767d\u8840\u75c5 \u2500 Heho\u5065\u5eb7\u7db2<\/strong><\/a><\/h2>\n\n\n\n

    \u967d\u660e\u7834\u89e3\u767d\u8840\u75c5\u81f4\u764c\u6a5f\u8f49\u627e\u51fa\u95dc\u9375\u5f71\u97ff\u57fa\u56e0| \u8840\u764c| \u764c\u75c7 \u2500\u5143\u6c23\u7db2<\/strong><\/a><\/h3>\n\n\n\n

     \u8840\u764c\u6210\u56e0\u627e\u5230\u4e86\uff01\u3000\u539f\u4f86\u662f\u8840\u7403\u5e79\u7d30\u80de\u4e3b\u5bb0\u56e0\u5b50\u906d\u57fa\u56e0\u7d81\u67b6\u2500\u5065\u5eb7\u91ab\u7642\u7db2<\/strong><\/a><\/h2>\n\n\n\n

    \u300c\u8840\u764c\u300d\u5147\u624b\u627e\u5230\u4e86\uff01\u967d\u660e\u5927\u5b78\u7814\u7a76\uff1a\u300c\u8840\u7403\u5e79\u7d30\u80de\u300d\u4e3b\u5bb0\u56e0\u5b50\u88ab\u7d81\u67b6\u2500ETtoday\u65b0\u805e\u96f2<\/strong><\/a><\/h2>\n\n\n\n

    \u570b\u5916\u5408\u4f5c\u5be6\u9a57\u5ba4<\/strong><\/h1>\n\n\n\n

    Dr. Robert G. Roeder\u2014The Rockefeller University<\/a><\/p>\n\n\n\n

    Dr. Gang Greg Wang\u2014UNC Lineberger Comprehensive Cancer Center<\/a><\/p>\n\n\n\n

    \u7814\u7a76\u8457\u4f5c *corresponding <\/h1>\n\n\n\n

    Kuan Y, Chu HF, Hsu PH, Hsu KC, Lin TH, Huang CH*, and Chen WY*<\/u>. (2024) Disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site. <\/mark>International Journal of Biological Macromolecules 276, 133955<\/em> (non-MDPI journal<\/strong>)<\/p>\n\n\n\n

    Cheng IH, Pi WC, Hsu CH, Guo Y, Lai JL, Wang GG, Chung Bc, Roeder RG, and Chen WY*<\/u>. (2024) TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes.<\/mark> Cell Death Discovery 10: 244<\/em><\/p>\n\n\n\n

    Liao CC, Wang YS, Pi WC, Wang CH, Wu YM, Chen WY*<\/u>, and Hsia KC*. (2023) Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein. <\/mark>Nature Communications 14: 5518 <\/em><\/p>\n\n\n\n

    Rosal KG, Chen W-Y<\/u>, Chung Bc. (2022) The A’-helix of CYP11A1 remodels mitochondrial cristae. <\/mark>Journal of Biomedical Science 29: 61<\/em><\/p>\n\n\n\n

    Ren Z, Kim A, Huang Y-T, Pi W-C, Gong W, Yu X, Qi J, Jin Jian, Cai L, Roeder RG*, Chen W-Y*<\/u>, Wang GG*. A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. <\/mark>PNAS 2022, 119, e2122940119 (2020 IF: 11.205)<\/em><\/p>\n\n\n\n

    Wang J, Yu X, Gong W, Liu X, Park K-S, Ma A, Tsai Y-H, Shen Y, Onikubo T, Pi W-C, Allison DF, Liu J, Chen W-Y<\/u>, Cai L, Roeder RG, Jin J* and Wang GG*. EZH2 non-canonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.<\/mark> Nature Cell Biology 2022, https:\/\/doi.org\/10.1038\/s41556-022-00850-x<\/a> (2020 IF: 28.824)<\/em><\/p>\n\n\n\n

    Huang YT, Cheng AC, Tang HC, Huang GC, Cai L, Lin TH, Wu KJ, Tseng PH, Wang GG, and Chen W-Y*<\/u>. <\/em>USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53- deficient lung cancer. <\/span>Cell Death & Disease 2021: 12, 880. (2020 IF: 8.469) <\/em><\/p>\n\n\n\n

    Chu HF, Cheng SC, Sun CY, Chou CY, Lin TH*, and Chen W-Y*<\/u>. Structural and biochemical characterization of PEDV papain-like protease 2.<\/mark> J Virology 2021: 96, e01372-21 (2020 IF: 5.103)<\/em><\/p>\n\n\n\n

    Lee Y-L, Ito K, Pi W-C, Lin I-H, Chu C-S, Malik S, Cheng I-H, Chen W-Y<\/u>*,<\/em> and Roeder RG*. Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth. <\/mark>PNAS 2021; 118, e1922864118 (2020 IF:11.205)<\/em>
    <\/p>\n\n\n\n

    Lin HC, Kuan Y, Chu HF, Cheng SC, Pan HC, Chen W-Y<\/u>, Sun CY*, Lin TH*. Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21.<\/mark> Int J Biol Macromol 2021: 176, 490-497 (2020 IF=6.953)<\/em><\/p>\n\n\n\n

    Fan H, Lu J, Guo Y, Li D, Zhang ZM, Tsai YH, Pi W-C, Ahn JH, Gong W, Xiang Y, Allison DF, Geng H, He S, Diao Y, Chen W-Y<\/u>, Strahl BD, Cai L, Song J, <\/em>Wang GG. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. <\/mark>Nature Genetics 2020: 52, 1384-1396. (2020 IF: 38.330)<\/em><\/p>\n\n\n\n

    Pi W-C, Wang J, Shimada M, Lin JW, Geng H, Lee Y-L, Li D, Wang GG, Roeder RG*, Chen W-Y<\/u>*. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. <\/mark>Blood 2020; 136, 11-23 (2020 IF: 23.629) (Plenary Article)<\/em><\/p>\n\n\n\n

    Wang X, Gerber A, Chen W-Y<\/u>, Roeder RG. Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development.<\/mark> PNAS 2020; 117, 15702-15711 (2020 IF: 11.205)<\/em><\/p>\n\n\n\n

    Liao C-C, Shankar S, Pi W-C, Chang C-C, Ahmed GR, Chen W-Y<\/u>, Hsia K-C. Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression under saline stress.<\/mark> EMBO reports 2020; 21, e48324 (2020 IF: 8.807)<\/em> <\/p>\n\n\n\n

    Liu CF, Tseng CH, Huang CY, Sun CC, Yang ML, Chen W-Y*<\/u>, and Yeung L*. Correlation between Higher-Order Aberrations and Visual Acuity Recovery (CoHORT) after Spectacles Treatment for Pediatric Refractive Amblyopia: A Pilot Study Using iDesign Measurement.<\/mark> <\/em>PLoS One 2020\uff1b15, e0229822. (2020 IF: 3.24) <\/em><\/p>\n\n\n\n

    Shimada M, Chen W-Y<\/u>, Nakadai T, Onikubo T, Guermah M, Rhodes D, Roeder RG. Gene-Specific H1 Eviction through a Transcriptional Activator\u2192p300\u2192NAP1\u2192H1 Pathway.<\/span> Molecular Cell 2019; 74, 268-283. (IF: 15.584)<\/em><\/p>\n\n\n\n

    Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen W-Y<\/u>, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O. Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.<\/span> Developmental Cell 2019; 48, 184-199. (IF: 10.092)<\/em> <\/p>\n\n\n\n

    Chen YL, Hu CM, Hsu JT, Chang CC, Huang TY, Chiang PH, Chen W-Y<\/u>, Chang YT, Chang MC, Tien YW, Lee EY, Jeng YM, Lee WH. Cellular 5-hydroxylmethylcytosine content determines tumorigenic potential and prognosis of pancreatic ductal adenocarcinoma.<\/span> American Journal of Cancer Research 2018; 8, 2548-2563. (IF: 5.177)<\/em> <\/p>\n\n\n\n

    Jishage M, Yu X, Shi Y, Ganesan SJ, Chen W-Y<\/u>, Sali A, Chait BT, Asturias FJ, Roeder RG. Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.<\/span> Nature Structural and Molecular Biology 2018; 25, 859-867. (IF: 11.98)<\/em> <\/p>\n\n\n\n

    Wu HT, Kuo YC, Hung JJ, Huang CH, Chen W-Y<\/u>, Chou TY, Chen Y, Chen YJ, Chen YJ, Cheng WC, Teng SC, Wu KJ. K63-polyubiquitinated HAUSP deubiquitinates HIF-1\u03b1 and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.<\/span> Nature Communications 2016; 7, 13644. (IF: 12.121)<\/em> <\/p>\n\n\n\n

    Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen W-Y<\/u>, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.<\/span> Cancer Cell 2016; 30, 92-107. (IF: 26.602)<\/em> <\/p>\n\n\n\n

    Jiang BH, Chen W-Y<\/u>, Li HY, Chien Y, Chang WC, Hsieh PC, Wu P, Chen CY, Song HY, Chien CS, Sung YJ, Chiou SH. CHD1L regulated PARP1-driven Pluripotency and Chromatin Remodeling during the Early-stage Cell Reprogramming.<\/span> Stem Cells 2015; 33, 2961-2972. (IF: 6.022)<\/em> <\/p>\n\n\n\n

    Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen W-Y<\/u>, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, M\u00fcschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.<\/span> Cancer Cell 2015; 27, 409-425. (IF: 26.602)<\/em> <\/p>\n\n\n\n

    Cheng KW, Cheng SC, Chen W-Y<\/u>, Lin MH, Chuang SJ, Cheng IH, Sun CY, Chou CY. Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus.<\/span> Antiviral Research 2015; 115, 9-16. (IF 4.101)<\/em> <\/p>\n\n\n\n

    Chen C-H, Chen W-Y<\/u>, Lin S-F, and Wong RJ. Epithelial\u2013Mesenchymal Transition Enhances Response to Oncolytic Herpesviral Therapy Through Nectin-1.<\/span> Human Gene Therapy 2014; 25, 539-551. (IF: 4.273)<\/em> <\/p>\n\n\n\n

    Chen W-Y<\/u> , Zhang J, Geng H, Du Z, Nakadai T, and Roeder RG. A TAF4 coactivator function for E proteins that involves enhanced TFIID binding.<\/span> Genes and Development 2013; 27:1596-1609. (IF: 9.527)<\/em> <\/p>\n\n\n\n

    Tang Z, Chen W-Y<\/u>, Shimada M, Nguyen UTT, Kim J, Sun XJ, Sengoku T, McGinty RK, Fernandez JP, Muir TW, and Roeder RG. SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53.<\/span> Cell 2013; 154, 297-310. (IF: 38.637)<\/em> <\/p>\n\n\n\n

    Sun XJ, Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen W-Y<\/u>, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, and Roeder RG. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukemogenesis.<\/span> Nature 2013; 500: 93-97. (IF: 42.778)<\/em> <\/p>\n\n\n\n

    Cai L, Rothbart SB, Lu R, Xu B, Chen W-Y<\/u>, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, and Wang GG. An H3K36 methylation engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.<\/span> Molecular Cell 2013; 49: 571-582. (IF: 15.584)<\/em> <\/p>\n\n\n\n

    Geng H, Brennan S, Milne TA, Chen W-Y<\/u>, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, Luger SM, Lazarus H, Tallman MS, Rowe JM, Litzow MR, Guzman ML, Allis CD, Roeder RG, Muschen M, Paietta E, Elemento O, Melnick AM. Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia.<\/span> Cancer Discovery 2012; 2: 1004-1023. (IF: 29.497)<\/em> <\/p>\n\n\n\n

    Jiang H, Shukla A, Wang X, Chen W-Y<\/u>, Bernstein BE, and Roeder RG. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.<\/span> Cell 2011;144: 513-525. (IF: 38.637)<\/em> <\/p>\n\n\n\n

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