{"id":556,"date":"2021-03-09T09:14:22","date_gmt":"2021-03-09T01:14:22","guid":{"rendered":"https:\/\/biochem.nycu.edu.tw\/%e9%99%b3%e9%b4%bb%e9%9c%87\/"},"modified":"2023-07-25T14:31:07","modified_gmt":"2023-07-25T06:31:07","slug":"chen-hong-chen","status":"publish","type":"post","link":"https:\/\/biochem.nycu.edu.tw\/english\/faculty\/full-time\/chen-hong-chen\/","title":{"rendered":"Hong-Chen Chen , PhD ,\nProfessor"},"content":{"rendered":"
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\u5c08\u9577<\/mark>
\u816b\u7624\u751f\u7269\u5b78\u3001\u7d30\u80de\u751f\u7269\u5b78<\/h2>\n\n\n\n

\u8fa6\u516c\u5ba4<\/mark>
\u751f\u7269\u91ab\u5b78\u5927\u6a13 \u516d\u6a13 R608 \u5ba4<\/h2>\n\n\n\n

\u96fb\u8a71<\/mark>
886-2-28267123 (\u8fa6\u516c\u5ba4); 886-2-28267000#65653 (\u5be6\u9a57\u5ba4)<\/h2>\n\n\n\n

Email<\/mark>
hcchen1029@nycu.edu.tw<\/a> <\/h2>\n\n\n\n

ORCiD<\/mark>
0000-0002-1923-6019<\/a><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\u7d93\u6b77<\/h1>\n\n\n\n
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\n\u79d1\u6280\u90e8\u751f\u79d1\u53f8 \u53f8\u9577
\n\u79d1\u6280\u90e8\u751f\u79d1\u53f8\u751f\u5316\u53ca\u85e5\u7406\u91ab\u5b78\u5b78\u9580 \u53ec\u96c6\u4eba
\n\u884c\u653f\u9662\u751f\u6280\u7522\u696d\u7b56\u7565\u8aee\u8b70\u59d4\u54e1\u6703\u8b70(BTC)\u59d4\u54e1
\n\u7d93\u6fdf\u90e8\u751f\u6280\u91ab\u85e5\u7522\u696d\u767c\u5c55\u63a8\u52d5\u5c0f\u7d44\u59d4\u54e1
\n\u885b\u798f\u90e8\u9577\u671f\u7167\u9867\u8aee\u8a62\u6703\u59d4\u54e1
\n\u885b\u798f\u90e8\u764c\u75c7\u9632\u6cbb\u653f\u7b56\u59d4\u54e1\u6703\u59d4\u54e1
\n\u6559\u80b2\u90e8\u570b\u969b\u6578\u7406\u5b78\u79d1\u5967\u6797\u5339\u4e9e\u7af6\u8cfd\u8aee\u8a62\u6703\u8aee\u8a62\u59d4\u54e1
\n\u8ca1\u5718\u6cd5\u4eba\u8fb2\u696d\u79d1\u6280\u7814\u7a76\u9662\u8463\u4e8b
\n\u8ca1\u5718\u6cd5\u4eba\u570b\u5bb6\u5be6\u9a57\u7814\u7a76\u9662\u570b\u5bb6\u5be6\u9a57\u52d5\u7269\u4e2d\u5fc3\u8aee\u8b70\u59d4\u54e1
\n\u8ca1\u5718\u6cd5\u4eba\u9ad8\u7b49\u6559\u80b2\u8a55\u9451\u4e2d\u5fc3\u57fa\u91d1\u6703\u59d4\u54e1
\n\u8ca1\u5718\u6cd5\u4eba\u6c38\u4fe1\u674e\u5929\u5fb7\u91ab\u85e5\u57fa\u91d1\u6703\u300c\u674e\u5929\u5fb7\u91ab\u85e5\u79d1\u6280\u734e\u300d\u8a55\u5be9\u59d4\u54e1\u6703\u53ec\u96c6\u4eba
\n\u570b\u7acb\u967d\u660e\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662 \u9662\u9577
\n\u570b\u7acb\u967d\u660e\u5927\u5b78\u751f\u6280\u91ab\u7642EMBA\u73ed \u4e3b\u4efb
\n\u570b\u7acb\u967d\u660e\u5927\u5b78\u5206\u5b50\u91ab\u5b78\u535a\u58eb\u5b78\u4f4d\u5b78\u7a0b \u4e3b\u4efb
\n\u53f0\u7063\u806f\u5408\u5927\u5b78\u7cfb\u7d71\u8de8\u9818\u57df\u795e\u7d93\u79d1\u5b78\u535a\u58eb\u5b78\u4f4d\u5b78\u7a0b \u4e3b\u4efb
\n\u570b\u969b\u751f\u7269\u5316\u5b78\u53ca\u5206\u5b50\u751f\u7269\u5b78\u806f\u76df(IUBMB) \u53f0\u7063\u4ee3\u8868
\n\u4e9e\u6d32\u53ca\u5927\u6d0b\u6d32\u751f\u7269\u5316\u5b78\u5bb6\u53ca\u5206\u5b50\u751f\u7269\u5b78\u5bb6\u806f\u76df(FAOBMB) \u53f0\u7063\u4ee3\u8868
\n\u53f0\u7063\u751f\u7269\u5316\u5b78\u53ca\u5206\u5b50\u751f\u7269\u5b78\u5b78\u6703 \u7406\u4e8b\u9577
\n\u53f0\u7063\u751f\u7269\u5316\u5b78\u53ca\u5206\u5b50\u751f\u7269\u5b78\u5b78\u6703 \u7406\u4e8b\u3001\u76e3\u4e8b
\n\u4e2d\u83ef\u6c11\u570b\u7d30\u80de\u53ca\u5206\u5b50\u751f\u7269\u5b78\u5b78\u6703 \u7406\u4e8b
\n\u53f0\u7063\u57fa\u56e0\u9ad4\u66a8\u907a\u50b3\u5b78\u6703 \u7406\u4e8b
\n\u7f8e\u570b\u5bc6\u897f\u6839\u5927\u5b78\u91ab\u5b78\u7cfb \u8a2a\u554f\u6559\u6388
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u6821\u53cb\u7e3d\u6703 \u9867\u554f
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662 \u9662\u9577
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6240 \u5275\u6240\u6240\u9577
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u4e2d\u5fc3 \u7d44\u9577
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb \u526f\u6559\u6388\u3001\u6559\u6388
\n\u7f8e\u570b\u5eb7\u4e43\u723e\u5927\u5b78\u5206\u5b50\u91ab\u5b78\u7cfb \u535a\u58eb\u5f8c\u7814\u7a76\u54e1
\n<\/p>\n\n\n\n

\u69ae\u8b7d<\/h1>\n\n\n\n
\n
\n

\n\u79d1\u6280\u90e8\u5091\u51fa\u7814\u7a76\u734e (2003\u30012015)
\n\u4e2d\u592e\u7814\u7a76\u9662\u5e74\u8f15\u5b78\u8005\u7814\u7a76\u8457\u4f5c\u734e
\n\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u8b1b\u5ea7\u6559\u6388
\n\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u5091\u51fa\u6559\u7814\u4eba\u54e1
\n\u570b\u7acb\u967d\u660e\u5927\u5b78\u8b1b\u5ea7\u6559\u6388
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u69ae\u8b7d\u7279\u8058\u6559\u6388
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u7279\u8058\u6559\u6388
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u5efa\u6559\u5408\u4f5c\u8a08\u756b\u7e3e\u512a\u734e
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u5091\u51fa\u9752\u5e74\u6559\u5e2b\u7814\u7a76\u734e
\n\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u300c\u8208\u5927\u4e4b\u5149\u300d\u734e\u724c
\n\u570b\u969b\u751f\u5316\u53ca\u5206\u5b50\u751f\u7269\u5b78\u806f\u76df(IUBMB)2014\u5e74\u8f15\u79d1\u5b78\u5bb6\u8ad6\u58c7\u4e3b\u5e2d
\n\u7ff0\u6797\u51fa\u7248\u793e108\u8ab2\u7db1\u9ad8\u4e2d\u751f\u7269\u8ab2\u672c\u300cCareer in Biology) \u5c08\u6b04\u4ecb\u7d39
\n\u79d1\u6280\u90e8\u79d1\u6280\u5927\u89c0\u5712\u4eba\u7269\u5c08\u8a2a
\n<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u6307\u5c0e\u5b78\u751f\u7372\u734e<\/h1>\n\n\n\n
\n
\n

2023 \u6307\u5c0e\u535a\u58eb\u5f8c\u8303\u5609\u6995\u69ae\u737237\u5c46\u751f\u91ab\u5e74\u6703 \u7d30\u5206\u5b78\u6703\u674e\u5929\u5fb7\u58c1\u5831\u8ad6\u6587\u734e \u512a\u7b49\u734e
2021 \u6307\u5c0e\u535a\u58eb\u5f8c\u8303\u5609\u6995\u69ae\u7372109\u5e74\u5ea6\u79d1\u6280\u90e8\u535a\u58eb\u5f8c\u7814\u7a76\u4eba\u54e1\u7814\u7a76\u5b78\u8853\u734e
2019 \u6307\u5c0e\u535a\u58eb\u5f8c\u8a31\u6587\u99a8\u69ae\u7372\u7b2c\u4e8c\u5341\u4e03\u5c46\u4e2d\u83ef\u6c11\u570b\u7d30\u80de\u53ca\u5206\u5b50\u751f\u7269\u5b78\u5b78\u6703\u300c\u5f90\u5343\u7530\u512a\u79c0\u8ad6\u6587\u7af6\u8cfd\u7b2c\u4e8c\u540d\u300d
2018 \u6307\u5c0e\u535a\u58eb\u5f8c\u8a31\u6587\u99a8\u69ae\u7372\u53f0\u7063\u751f\u5316\u53ca\u5206\u751f\u5b78\u6703\u79cb\u4ee4\u71df\u82f1\u6587\u53e3\u982d\u8ad6\u6587\u7af6\u8cfd\u7b2c\u4e00\u540d
2018 \u6307\u5c0e\u535a\u58eb\u751f\u8a31\u6587\u99a8\u69ae\u7372\u4e2d\u570b\u91ab\u85e5\u5927\u5b782018\u751f\u7269\u91ab\u5b78\u570b\u969b\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587\u7279\u512a\u734e
2018 \u6307\u5c0e\u7814\u7a76\u751f\u891a\u749f\u5f64\u69ae\u7372\u4e2d\u570b\u91ab\u85e5\u5927\u5b782018\u751f\u7269\u91ab\u5b78\u570b\u969b\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587\u7279\u512a\u734e
2018 \u6307\u5c0e\u5927\u5b78\u751f\u984f\u777f\u826f\u69ae\u7372106\u5b78\u5e74\u5ea6\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u7cfb\u5b78\u58eb\u7562\u696d\u8ad6\u6587\u7279\u512a\u734e
2018 \u6307\u5c0e\u7814\u7a76\u751f\u891a\u749f\u5f64\u69ae\u7372\u7b2c\u4e09\u5341\u4e09\u5c46\u751f\u7269\u91ab\u5b78\u806f\u5408\u5b78\u8853\u5e74\u6703\u512a\u79c0\u58c1\u5831\u8ad6\u6587\u734e
2016 \u6307\u5c0e\u53f0\u4e2d\u5973\u4e2d\u674e\u5cb1\u82b8\u69ae\u7372\u5168\u570b\u4e2d\u5c0f\u5b78\u79d1\u5c55\u52d5\u7269\u8207\u91ab\u5b78\u7d44\u7b2c\u4e8c\u540d
2016 \u6307\u5c0e\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u9673\u5efa\u9716\u69ae\u7372\u4e2d\u570b\u91ab\u85e5\u5927\u5b782016\u751f\u7269\u91ab\u5b78\u570b\u969b\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587 \u7279\u512a\u734e
2016 \u6307\u5c0e\u7814\u7a76\u751f\u6797\u5b9b\u5100\u69ae\u7372\u4e2d\u570b\u91ab\u85e5\u5927\u5b782016\u751f\u7269\u91ab\u5b78\u570b\u969b\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587\u4f73\u4f5c
2016 \u6307\u5c0e\u7814\u7a76\u751f\u90ed\u5072\u7433\u69ae\u7372\u7b2c\u4e09\u5341\u4e00\u5c46\u751f\u7269\u91ab\u5b78\u806f\u5408\u5b78\u8853\u5e74\u6703\u512a\u79c0\u58c1\u5831\u8ad6\u6587\u734e
2015 \u6307\u5c0e\u7814\u7a76\u751f\u8a31\u6587\u99a8\u69ae\u73722015\u5e74\u751f\u79d1\u61f6\u4eba\u5305\u4e09\u5206\u9418\u53e3\u8aaa\u8ad6\u6587\u5168\u570b\u7af6\u8cfd\u6700\u4f73\u4eba\u6c23\u734e
2015 \u6307\u5c0e\u7814\u7a76\u751f\u5f35\u73c0\u744b\u69ae\u7372102\u5b78\u5e74\u5ea6\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u7cfb\u78a9\u58eb\u7562\u696d\u8ad6\u6587\u7279\u512a\u734e
2015 \u6307\u5c0e\u5927\u5b78\u751f\u738b\u5955\u52db\u69ae\u7372102\u5b78\u5e74\u5ea6\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u7cfb\u5b78\u58eb\u7562\u696d\u8ad6\u6587\u7279\u512a\u734e
2014 \u6307\u5c0e\u7814\u7a76\u751f\u5f35\u73c0\u744b\u69ae\u7372\u53f0\u7063\u57fa\u56e0\u9ad4\u66a8\u907a\u50b3\u5b78\u67032014\u8f49\u8b6f\u91ab\u5b78\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587\u734e
2014 \u6307\u5c0e\u7814\u7a76\u751f\u8a31\u6587\u99a8\u69ae\u7372\u53f0\u7063\u57fa\u56e0\u9ad4\u66a8\u907a\u50b3\u5b78\u67032014\u8f49\u8b6f\u91ab\u5b78\u7814\u8a0e\u6703\u58c1\u5831\u8ad6\u6587\u734e
2014 \u6307\u5c0e\u7814\u7a76\u751f\u8521\u5b9b\u81fb\u69ae\u7372102\u5b78\u5e74\u5ea6\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u7cfb\u78a9\u58eb\u7562\u696d\u8ad6\u6587\u7279\u512a\u734e
2014 \u6307\u5c0e\u5927\u5b78\u751f\u859b\u96c5\u6587\u69ae\u7372102\u5b78\u5e74\u5ea6\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u7cfb\u5b78\u58eb\u7562\u696d\u8ad6\u6587\u7279\u512a\u734e
2014 \u6307\u5c0e\u7814\u7a76\u751f\u8521\u5b9b\u81fb\u69ae\u7372\u7b2c\u4e8c\u5341\u4e5d\u5c46\u751f\u7269\u91ab\u5b78\u806f\u5408\u5b78\u8853\u5e74\u6703\u512a\u79c0\u58c1\u5831\u8ad6\u6587\u734e
2013 \u6307\u5c0e\u7814\u7a76\u751f\u6f58\u7fbf\u6c5d\u69ae\u7372\u300c\u7b2c\u4e5d\u5c46\u6c38\u4fe1\u674e\u5929\u5fb7\u91ab\u85e5\u79d1\u6280\u734e\u300d\u4e4b\u5091\u51fa\u8ad6\u6587\u734e
2013 \u6307\u5c0e\u535a\u58eb\u5f8c\u8a79\u535a\u5146\u69ae\u73722013\u5e74\u53f0\u7063\u751f\u5316\u53ca\u5206\u751f\u5b78\u6703\u51ac\u4ee4\u71df\u512a\u79c0\u58c1\u5831\u8ad6\u6587\u734e
2013 \u6307\u5c0e\u7814\u7a76\u751f\u8a31\u6587\u99a8\u69ae\u73722013\u5e74\u53f0\u7063\u751f\u5316\u53ca\u5206\u751f\u5b78\u6703\u51ac\u4ee4\u71df\u512a\u79c0\u58c1\u5831\u8ad6\u6587\u734e
2012 \u6307\u5c0e\u7814\u7a76\u751f\u738b\u8212\u6167\u69ae\u73722012\u5e74\u53f0\u7063\u751f\u5316\u53ca\u5206\u751f\u5b78\u6703\u51ac\u4ee4\u71df\u53e3\u982d\u8ad6\u6587\u7af6\u8cfd(\u78a9\u73ed\u7d44 ) \u7b2c\u4e00\u540d
2012 \u6307\u5c0e\u7814\u7a76\u751f\u6f58\u7fbf\u6c5d\u69ae\u73722012\u5e74\u53f0\u7063\u751f\u5316\u53ca\u5206\u751f\u5b78\u6703\u51ac\u4ee4\u71df\u53e3\u982d\u8ad6\u6587\u7af6\u8cfd(\u535a\u73ed\u7d44 ) \u7b2c\u4e8c\u540d
2012 \u6307\u5c0e\u7814\u7a76\u751f\u6f58\u7fbf\u6c5d\u69ae\u7372\u7b2c\u4e5d\u5c46\u6797\u69ae\u8000\u6559\u6388\u5b78\u8853\u6559\u80b2\u57fa\u91d1\u6703\u512a\u79c0\u8ad6\u6587\u734e
2012 \u6307\u5c0e\u5927\u5b78\u751f\u8a31\u6587\u99a8\u69ae\u7372100\u5b78\u5e74\u5ea6\u4e2d\u8208\u5927\u5b78\u751f\u79d1\u7cfb\u5b78\u58eb\u7562\u696d\u8ad6\u6587\u7279\u512a\u734e
2012 \u6307\u5c0e\u7814\u7a76\u751f\u6f58\u7fbf\u6c5d\u69ae\u73722012\u8f49\u8b6f\u91ab\u5b78\u4e4b\u57fa\u56e0\u9ad4\u8207\u86cb\u767d\u8cea\u9ad4\u81e8\u5e8a\u61c9\u7528\u7814\u8a0e\u6703\u58c1\u5831 \u8ad6\u6587\u7af6\u8cfd\u7b2c\u4e00\u540d
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2011 \u6307\u5c0e\u7814\u7a76\u751f\u6f58\u7fbf\u6c5d\u69ae\u7372\u7b2c\u4e8c\u5341\u516d\u5c46\u751f\u7269\u91ab\u5b78\u806f\u5408\u5b78\u8853\u5e74\u6703\u512a\u79c0\u58c1\u5831\u8ad6\u6587\u734e
<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u7814\u7a76\u8208\u8da3<\/h1>\n\n\n\n

\u63a2\u8a0e\u7d30\u80de\u764c\u5316\u7684\u6a5f\u8f49:
(1) \u764c\u7d30\u80de\u79fb\u52d5\u7684\u6a5f\u8f49
(2) \u4e2d\u9593\u7d72\u9aa8\u67b6\u86cb\u767d\u5728\u7d30\u80de\u764c\u5316\u904e\u7a0b\u4e2d\u7684\u89d2\u8272<\/p>\n\n\n\n

\u7814\u7a76\u8457\u4f5c<\/h1>\n\n\n\n

Fan, J.-R., Chang, S.-N., Chu, C.-T., and Chen, H.-C.*<\/u> (2023). AKT2-mediated nuclear deformation leads to genome instability during epithelial-mesenchymal transition.<\/mark> iScience <\/em>26:106992<\/p>\n\n\n\n

Chen, Y.-H., Hsu, J.-Y., Chu, C.-T., Chang, Y.W., Fan, J.-R., Yang, M.-H., and Chen, H.-C.*<\/u> (2022). Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation.<\/mark> Life Science Alliance<\/em> e202201529.<\/p>\n\n\n\n

Chu, C.-T., Chen, Y.-H., Chiu, W.-T.,  Chen, H.-C.*<\/u>  (2021). Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase.<\/strong><\/span> <\/em>Life science alliance, 4(10), e202101120.<\/em><\/p>\n\n\n\n

Fan, J.-R., You, L.-R., Wang, W.-J., Huang, W.-S., Chu, C.-T., Chi, Y.-H., Chen, H.-C.*<\/u> (2020). Lamin A\u2010mediated nuclear lamina integrity is required for proper ciliogenesis.<\/span> EMBO Reports, e49680<\/em>.<\/p>\n\n\n\n

Su, C.-Y., Yan, R.-L., Hsu, W.-U., Chu, C.-T., Chang, H.-C., Lai, C.-C., Hsu, H.-P., Chen, H.-C.* <\/u> (2019). Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration.<\/span> Scientific Reports 9(1):13703<\/em>.<\/p>\n\n\n\n

Yang, C.-Y., Chang, P.-W., Hsu, W.-H., Chang, H.-C., Chen, C.-L., Lai , C.-C., Chiu, W.-T.,and Chen, H.-C.*<\/u> (2019). Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration.<\/span> Oncogene 2019 May ;38(21):4075-4094.<\/em><\/p>\n\n\n\n

Kuo, S.-L., Chen, C.-L., Pan, Y.-R., Chiu, W.-T., and Chen, H.-C.*<\/u> (2018). Biogenesis of podosome rosettes through fission.<\/span> Scientific Reports 8: 524.<\/em><\/p>\n\n\n\n

Hsu, W., Wang, W., Lin, W., Huang, Y., Lai, C., Liao, J., and Chen, H.-C.*<\/u> (2018). Adducin\u20101 is essential for spindle pole integrity through its interaction with TPX2.<\/span> EMBO Reports 19(8), e45607.<\/em><\/p>\n\n\n\n

Liu, C.-M., Hsu, W.-H., Lin, W.-Y., and Chen, H.-C.*<\/u> (2017). Adducin family proteins possess different nuclear export potentials.<\/span> Journal of Biomedical Science 24: 30.<\/em><\/p>\n\n\n\n

Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC<\/u>, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL.* (2016). HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms.<\/span> Oncogene 35:5674-5685.<\/em><\/p>\n\n\n\n

Chen, C.-L., Wang, S.-H., Chan, P.-C., and Chen, H.-C.*<\/u> (2016). Phosphorylation of E-cadherin at threonine 790 by protein kinase Cd suppresses the function of E-cadherin.<\/span> Oncotarget 7: 37260-37276.<\/em><\/p>\n\n\n\n

Tsai, W.-C., Chen, C.-L., and Chen, H.-C.*<\/u>(2015). Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling.<\/span> Oncotarget 6:23845-23856.<\/em><\/p>\n\n\n\n

Chang, C.-H., Chan, P.-C., Li, J.-R., Chen, C.-J., Shieh, J.-J., Fu, Y.-C., Chen, H.-C.<\/u>, and Wu, M-.J.* (2015). Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma.<\/span> Oncotarget 6:1478-1489.<\/em><\/p>\n\n\n\n

Chan, P.-C. Hsu, R. Y. C., Liu, C.-W., Lai, C.-C., and Chen, H.-C.*<\/u> (2014). Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X.<\/span> <\/em>Journal of Cell Biology 204:19-28. (highlighted article)<\/em><\/p>\n\n\n\n

Pan., Y.-R., Tseng, W.-S., Chang, P.-W., and Chen, H.-C.*<\/u> (2013). Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts.<\/span> Journal of Cell Science 126:5670-5680. (cover article)<\/em><\/p>\n\n\n\n

Hsieh, Y.-T., Chou, M.\u2013M., Chen, H.-C.,*<\/u> and Tseng, J.-J.* (2013). IMP1 promotes choriocarcinoma cell migration and invasion through novel effectors RSK2 and PPME1. <\/span>Gynecological Oncology 131: 182-190.<\/em><\/p>\n\n\n\n

Pan, Y.-R., Cho, K.-H., Lee, H.-H., Chang, Z.-F., and Chen, H.-C.*<\/u> (2013). Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts.<\/span> <\/em>Journal of Cell Science 126:(2) 657-666.<\/em><\/p>\n\n\n\n

Chan, P.-C. and Chen, H.-C.*<\/u> (2012). P120RasGAP-medaited activation of c-Src is critical for oncogenic Ras to induce tumor invasion. <\/span>Cancer Research72: 2405-2415.<\/em><\/p>\n\n\n\n

Pan, Y.-R., Chen, C.-L., and Chen, H.-C.*<\/u> (2011). FAK is required for the assembly of podosome rosettes.<\/span> Journal of Cell Biology 195: 113-129.<\/em><\/p>\n\n\n\n

Chen, C.-L., Lin, Y.-P., Lai, Y.-C., and Chen, H.-C.*<\/u> (2011). a-Adducin translocates to the nucleus upon loss of cell-cell adhesions.<\/span> Traffic 12: 1327-1340.<\/em><\/p>\n\n\n\n

Lu, Y.-C. and Chen, H.-C.*<\/u> (2011). Involvement of lipid rafts in adhesion-induced activation of Met and EGFR.<\/span> Journal of Biomedical Science 18:78.<\/em><\/p>\n\n\n\n

Chen, T.-H., Chan, P.-C., Chen, C.-L., and Chen, H.-C.*<\/u> (2011). Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition.<\/span> Oncogene 30: 153-166.<\/em><\/p>\n\n\n\n

Chan, P.-C., Sudhakar, J. N., Lai, C.-C., and Chen, H.-C.*<\/u> (2010). Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions.<\/span> Oncogene 29: 698-710.<\/em><\/p>\n\n\n\n

Chen, C.-L., Chan, P.-C., Wang, S.-H., Pan, Y.-R., and Chen, H.-C.*<\/u> (2010). Elevated expression of protein kinase Cd induces cell scattering upon serum deprivation.<\/span> Journal of Cell Science 123: 2901-2913. (highlighted article)<\/em><\/p>\n\n\n\n

Lee, W.-C., Chen, H.-C.<\/u>, Wang, C.-Y., Lin, P.-Y., Ou, T.-T., Chen, C.-C., Wen, M.-C., Wang, J., and Lee, H.-J.* (2010). Cilostazol ameliorates nephropathy in type I diabetic rats involving in oxidative stress and regulation of TGFb and NFkB.Biosci.<\/em><\/span> Biotechnol. Biochem.74: 1355-1361.<\/em><\/p>\n<\/div>\n<\/div>\n\n\n\n

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