{"id":559,"date":"2025-10-28T09:01:22","date_gmt":"2025-10-28T01:01:22","guid":{"rendered":"https:\/\/biochem.nycu.edu.tw\/%e5%a7%9c%e7%82%ba%e4%b8%ad\/"},"modified":"2025-10-28T15:24:43","modified_gmt":"2025-10-28T07:24:43","slug":"chiangwei-chung","status":"publish","type":"post","link":"https:\/\/biochem.nycu.edu.tw\/english\/faculty\/full-time\/chiangwei-chung\/","title":{"rendered":"Wei-Chung Chiang , PhD , Assistant Professor"},"content":{"rendered":"
\n
\n
\n
\n
\n
<\/div>\n\n\n\n
\n
\"\"<\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
\n
\n
\n

\u5c08\u9577<\/mark>
\u7d30\u80de\u81ea\u566c\u7814\u7a76\u3001\u7c92\u7dda\u9ad4\u751f\u7269\u5b78\u3001 \u8001\u5316\u751f\u7269\u5b78\u3001\u7d30\u80de\u81ea\u566c\u8a98\u5c0e\u85e5\u7269\u3001\u9ad8\u901a\u91cf\u85e5\u7269\u7be9\u9078 <\/h2>\n\n\n\n

\u5b78\u6b77<\/mark>
Ph.D., Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, U.S.A.<\/h2>\n\n\n\n

\u7d93\u6b77<\/mark>
Post-doctoral researcher, Center for Autophagy Research, UT-Southwestern Medical Center, Dallas, Texas, U.S.A<\/h2>\n\n\n\n

\u8fa6\u516c\u5ba4<\/mark>
\u751f\u7269\u91ab\u5b78\u5927\u6a13 \u4e94\u6a13 R506 \u5ba4<\/h2>\n\n\n\n

\u96fb\u8a71<\/mark>
886-2-2826-7127<\/h2>\n\n\n\n

Email<\/mark>
wchiang@nycu.edu.tw<\/a><\/h2>\n\n\n\n

\u500b\u4eba\u7db2\u7ad9<\/mark>
https:\/\/wchiang4.wixsite.com\/chianglab<\/a><\/h2>\n\n\n\n

ORCiD<\/mark>
0000-0003-3149-435X<\/a><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\u5b78\u7d93\u6b77<\/h1>\n\n\n\n
\n
\n

2018 \u8fc4\u4eca
2013-2018

2012<\/p>\n<\/div>\n\n\n\n

\n

\u570b\u7acb\u967d\u660e\u5927\u5b78 \u751f\u5316\u66a8\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240 \u52a9\u7406\u6559\u6388
Center for Autophagy Research, UT-Southwestern Medical Center \u7f8e\u570b\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3 \u7d30\u80de\u81ea\u566c\u7814\u7a76\u4e2d\u5fc3 \u535a\u58eb\u5f8c\u7814\u7a76\u54e1
Department of Molecular and Integrative Physiology, University of Michigan \u7f8e\u570b\u5bc6\u897f\u6839\u5927\u5b78 \u751f\u7406\u5b78\u7814\u7a76\u6240\u535a\u58eb<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u69ae\u8b7d<\/h1>\n\n\n\n
\n
\n

2021
2020
2020
2019
2019
2014-2018<\/p>\n<\/div>\n\n\n\n

\n

\u570b\u7acb\u967d\u660e\u5927\u5b78\u91ab\u5b78\u7cfb\u512a\u826f\u6559\u5e2b\u7409\u7483\u734e\u5ea7
\u570b\u885b\u9662CDG\u7814\u7a76\u8a08\u756b
\u79d1\u6280\u90e8\u512a\u79c0\u9752\u5e74\u5b78\u8005\u8a08\u756b
\u6c88\u529b\u63da\u6559\u6388\u57fa\u91d1\u6703 \u8b1b\u5e2b\u7d1a\u7814\u7a76\u8207\u9032\u4fee\u734e\u52a9
\u570b\u7acb\u967d\u660e\u5927\u5b78\u91ab\u5b78\u9662 \u5b78\u751f\u7db2\u8def\u6559\u5b78\u8a55\u4f30\u512a\u826f\u6559\u5e2b
Centers of Excellence for Translational Research (CETR) Traineeship<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u6307\u5c0e\u5b78\u751f\u7372\u734e<\/h1>\n\n\n\n
\n
\n

2025
2024
2023 2023 2022 2021 2021 2021 2020
2019<\/p>\n<\/div>\n\n\n\n

\n

\u5927\u5c08\u751f \u9ec3\u67cf\u745c\u7372\u79d1\u6280\u90e8\u5927\u5c08\u751f\u8a08\u756b\u88dc\u52a9
\u5927\u5c08\u751f \u5433\u4f73\u8afa\u7372\u5e74\u5ea6\u5065\u5eb7\u79d1\u5b78\u6587\u6559\u57fa\u91d1\u6703\/\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u300c\u7b2c 19 \u5c46\u91ab\u5b78\u7cfb\u5b78\u751f\u6691\u671f\u7814\u7a76\u8a08\u756b\u300d\u88dc\u52a9
\u674e\u6c9b\u9756 \u53f0\u7063\u7c92\u7dda\u9ad4\u5b78\u6703\u5e74\u6703 \u58c1\u5831\u7af6\u8cfd\u4f73\u4f5c\u734e
\u6797\u6021\u8fb0 \u751f\u7269\u91ab\u5b78\u5e74\u6703 \u58c1\u5831\u7af6\u8cfd\u512a\u52dd
\u5927\u5c08\u751f \u5433\u4f73\u8afa\u7372\u79d1\u6280\u90e8\u5927\u5c08\u751f\u8a08\u756b\u88dc\u52a9
\u90ed\u9756 \u53f0\u7063\u7c92\u7dda\u9ad4\u5b78\u6703\u5e74\u6703 \u58c1\u5831\u7af6\u8cfd\u7b2c\u4e09\u540d
\u5289\u6c9b\u51fd \u53f0\u7063\u7c92\u7dda\u9ad4\u5b78\u6703\u5e74\u6703 \u58c1\u5831\u7af6\u8cfd\u4f73\u4f5c\u734e
\u6731\u744b\u83ef \u751f\u5316\u6240\u78a9\u58eb\u73ed\u512a\u826f\u8ad6\u6587\u8a55\u6bd4 \u7b2c\u4e09\u540d
\u5b6b\u7dad\u6fa4 \u751f\u7269\u91ab\u5b78\u5e74\u6703 \u58c1\u5831\u7af6\u8cfd\u512a\u52dd
\u90ed\u9756 \u53f0\u7063\u7c92\u7dda\u9ad4\u5b78\u6703\u5e74\u6703 \u512a\u79c0\u8ad6\u6587\u58c1\u5831\u734e<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u6307\u5c0e\u5b78\u751f\u51fa\u570b\u9032\u4fee<\/strong><\/h2>\n\n\n\n
\n
\n

2022<\/p>\n<\/div>\n\n\n\n

\n

\u90ed\u9756  \u7f8e\u570b\u7f85\u5fb9\u65af\u7279\u5927\u5b78 (University of Rochester)  \u535a\u58eb\u73ed<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u5c08\u5229\u8207\u6280\u8f49<\/h1>\n\n\n\n
\n
\n

\u5c08\u5229\u540d\u7a31

\u767c\u660e\u4eba

\u6280\u8f49<\/p>\n<\/div>\n\n\n\n

\n

Small molecule inducers of autophagy that function by disrupting Beclin 1\/ Bcl-2 binding (\u7d30\u80de\u81ea\u566c\u8a98\u767c\u5c0f\u5206\u5b50\u85e5\u7269)
Jef DeBrabander, Qiren Liang, Beth Levine, Wei-Chung Chiang (\u59dc\u70ba\u4e2d)
US provision Filing No.\uff1a62680578 (Filing Date: 2018\u5e746\u67084\u65e5)
Casma Therapeutics<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u5c08\u9577\u2014 \u9078\u64c7\u6027\u81ea\u566c\u4f5c\u7528 (selective autophagy)\u3001\u7c92\u7dda\u9ad4\u81ea\u566c(mitophagy)\u8207\u76f8\u95dc\u75be\u75c5\u7814\u7a76<\/strong><\/h2>\n\n\n\n

\u7814\u7a76\u65b9\u5411<\/h1>\n\n\n\n

\u7c92\u7dda\u9ad4\u81ea\u566c\u4f5c\u7528 (Mitophagy)<\/strong><\/h2>\n\n\n\n

\u7c92\u7dda\u9ad4\u662f\u7d30\u80de\u7684\u767c\u96fb\u5ee0\u3001\u7522\u751f\u80fd\u91cf\u7684\u95dc\u9375\u80de\u5668\uff0c\u5c0d\u591a\u7a2e\u7d30\u80de\u751f\u7406\u904e\u7a0b\u81f3\u95dc\u91cd\u8981\u3002\u7c92\u7dda\u9ad4\u529f\u80fd\u7570\u5e38\u6703\u5c0e\u81f4\u6d3b\u6027\u6c27\u7269\u8cea\uff08ROS\uff09\u589e\u52a0\uff0c\u9032\u4e00\u6b65\u5f15\u767c\u767c\u708e\u9ad4\uff08inflammasome\uff09\u6fc0\u6d3b\u3001\u57fa\u56e0\u6bd2\u6027\uff08genotoxicity\uff09\u3001\u816b\u7624\u767c\u751f\u4ee5\u53ca\u8001\u5316\u7b49\u4e00\u7cfb\u5217\u554f\u984c\u3002\u56e0\u6b64\u7dad\u6301\u6b63\u5e38\u7684\u7c92\u7dda\u9ad4\u529f\u80fd\u5c0d\u65bc\u7d30\u80de\u5b58\u6d3b\u8207\u751f\u7269\u9ad4\u7684\u5065\u5eb7\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n\n\n\n

\u7576\u7d30\u80de\u9762\u5c0d\u74b0\u5883\u58d3\u529b(\u5982\u990a\u5206\u7f3a\u4e4f\u3001\u7f3a\u6c27)\u7b49\u4e0d\u5229\u56e0\u7d20\u6642\uff0c\u7d30\u80de\u80fd\u5920\u555f\u52d5\u8a31\u591a\u4fc3\u9032\u74b0\u5883\u9069\u61c9\u7684\u6a5f\u5236\u4ee5\u78ba\u4fdd\u5b58\u6d3b\u3002\u5176\u4e2d\u4e00\u7a2e\u6a5f\u5236 — \u81ea\u566c\u4f5c\u7528 (autophagy)\u70ba\u5e6b\u52a9\u7d30\u80de\u5728\u4e0d\u5229\u74b0\u5883\u4e0b\u5b58\u6d3b\u7684\u91cd\u8981\u53cd\u61c9\u3002\u7c92\u7dda\u9ad4\u81ea\u566c\uff08mitophagy\uff09\u662f\u4e00\u7a2e\u7279\u5b9a\u5f62\u5f0f\u7684\u81ea\u566c\u4f5c\u7528\uff0c\u91dd\u5c0d\u7c92\u7dda\u9ad4\u9032\u884c\u54c1\u8cea\u7ba1\u63a7\u3002\u901a\u904e\u6b64\u6a5f\u5236\uff0c\u771f\u6838\u7d30\u80de\u80fd\u5920\u9078\u64c7\u6027\u6e05\u9664\u591a\u9918\u6216\u640d\u58de\u7684\u7c92\u7dda\u9ad4\u4f86\u7dad\u6301\u7d30\u80de\u5065\u5eb7\u3002\u7576\u7c92\u7dda\u9ad4\u640d\u50b7\u6642\uff0c\u7c92\u7dda\u9ad4\u819c\u96fb\u4f4d\u7684\u4e0b\u964d\u6703\u5c0e\u81f4PINK1\uff08\u4e00\u7a2e\u7d72\u6c28\u9178\/\u8607\u6c28\u9178\u6fc0\u9176\uff09\u5728\u7c92\u7dda\u9ad4\u5916\u819c\uff08OMM\uff09\u4e0a\u7684\u7d2f\u7a4d\u3002\u7a69\u5b9a\u7684PINK1\u6703\u78f7\u9178\u5316\u8207\u7c92\u7dda\u9ad4\u5916\u819c\u86cb\u767d\u4e0a\u7684\u6cdb\u7d20\uff08ubiquitin\uff09\uff0c\u5f9e\u800c\u4f7fParkin\uff08\u4e00\u7a2e\u6cdb\u7d20E3\u9023\u63a5\u9176\uff09\u805a\u96c6\u5230\u640d\u58de\u7684\u7c92\u7dda\u9ad4\uff0cParkin\u5728\u5176\u4e0a\u5c0d\u591a\u500b\u5916\u819c\u86cb\u767d\u9032\u884c\u591a\u6cdb\u7d20\u5316\uff08polyubiquitination\uff09\u3002\u6700\u7d42\uff0c\u640d\u58de\u7684\u7c92\u7dda\u9ad4\u6703\u88ab\u6cdb\u7d20\u7d50\u5408\u7684\u81ea\u566c\u53d7\u9ad4\uff08autophagy receptors\uff09\u8b58\u5225\uff0c\u4e26\u4fc3\u9032\u7c92\u7dda\u9ad4\u81ea\u566c\u4f5c\u7528\u7684\u9032\u884c\u3002<\/p>\n\n\n\n

\u200b\u200b\u200b\u200b\u200b\u200b\u200b\u200b\u200b\u4ee5\u5f80\u95dc\u65bc\u7c92\u7dda\u9ad4\u81ea\u566c\u6a5f\u5236\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u7c92\u7dda\u9ad4\u5916\u819c\uff08OMM\uff09\u4e0a\u7684\u4e8b\u4ef6\uff0c\u5982PINK1\u3001Parkin\u7684\u6d3b\u5316\u3001\u5916\u819c\u86cb\u767d\u7684\u591a\u6cdb\u7d20\u5316\u4ee5\u53ca\u81ea\u566c\u53d7\u9ad4\u86cb\u767d\u7684\u62db\u52df\u3002\u7136\u800c\uff0c\u89f8\u767c\u7c92\u7dda\u9ad4\u81ea\u566c\u7684\u539f\u56e0\u5176\u5be6\u6e90\u81ea\u5728\u7c92\u7dda\u9ad4\u5167\u819c\u6216\u57fa\u8cea\u4e2d\u3002\u56e0\u6b64\uff0c\u5728\u7c92\u7dda\u9ad4\u5167\u90e8\u61c9\u5b58\u5728\u4e00\u4e9b\u5c1a\u672a\u767c\u73fe\u7684\u6a5f\u5236\u53ef\u4ee5\u4fc3\u9032\u7c92\u7dda\u9ad4\u81ea\u566c\u4f5c\u7528\u3002\u6709\u8da3\u7684\u662f\uff0c\u65e9\u671f\u7684\u7814\u7a76\u5df2\u7d93\u767c\u73fe\uff0c\u5728\u7c92\u7dda\u9ad4\u81ea\u566c\u904e\u7a0b\u4e2d\u6703\u767c\u751f\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\uff0c\u9019\u8868\u660e\u5728\u81ea\u566c\u904e\u7a0b\u4e2d\uff0c\u7c92\u7dda\u9ad4\u5167\u819c\u53ef\u80fd\u6703\u66b4\u9732\uff0c\u4e26\u88ab\u7d30\u80de\u8cea\u767c\u751f\u7684\u81ea\u566c\u4f5c\u7528\u8b58\u5225\u3002\u70ba\u4e86\u9a57\u8b49\u9019\u4e00\u5047\u8a2d\uff0c\u6211\u5011\u63a1\u7528\u4e86\u86cb\u767d\u8cea\u9ad4\u5b78\u65b9\u6cd5\uff0c\u8abf\u67e5\u5728\u7c92\u7dda\u9ad4\u81ea\u566c\u904e\u7a0b\u4e2d\uff0cIMM\u86cb\u767d\u662f\u5426\u6703\u8207LC3-II\uff08\u4e00\u7a2e\u81ea\u566c\u9ad4\u4e0a\u7684\u819c\u86cb\u767d\uff09\u76f8\u4e92\u4f5c\u7528\u3002\u6211\u5011\u767c\u73fe\u4e86\u4e00\u7a2e\u7c92\u7dda\u9ad4\u5167\u819c\u86cb\u767d Prohibitin 2\uff08PHB2\uff09\uff0c\u5728\u7c92\u7dda\u9ad4\u53bb\u6975\u5316\u8207\u5916\u819c\u5c40\u90e8\u7834\u88c2\u904e\u7a0b\u4e2d\u66b4\u9732\u65bc\u7d30\u80de\u8cea\u4e2d\uff0c\u4e26\u900f\u904e\u4e00\u500b\u5178\u578b\u7684LC3\u76f8\u4e92\u4f5c\u7528\u5340\u57df\uff08LIR\uff09\u8207LC3-II\u7d50\u5408\uff0c\u85c9\u6b64\u4ecb\u5c0e\u4e86\u640d\u58de\u7c92\u7dda\u9ad4\u7684\u8fa8\u8b58\u4ee5\u53ca\u81ea\u566c\u6e05\u9664\u3002\u56e0\u6b64\uff0c\u6211\u5011\u7684\u7814\u7a76\u63ed\u793a\u4e86\u7c92\u7dda\u9ad4\u5167\u819c\u7684\u66b4\u9732\u672c\u8eab\u53ef\u4ee5\u4f5c\u70ba\u4e00\u500b\u4fc3\u9032\u7c92\u7dda\u9ad4\u81ea\u566c\u4f5c\u7528\u7684\u6a5f\u5236\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u7814\u7a76\u65b9\u5411\u4e00\uff1a\u7c92\u7dda\u9ad4\u81ea\u566c\u8207\u8001\u5316\u3001\u8207\u5176\u4ed6\u751f\u7406\u529f\u80fd<\/strong>\uff08Mitophagy in longevity and healthiness)<\/h2>\n\n\n\n

\u9069\u7576\u53bb\u9664\u640d\u58de\u7684\u7c92\u7dda\u9ad4\u5c0d\u7dad\u6301\u6709\u6a5f\u9ad4\u7684\u7a69\u614b\u81f3\u95dc\u91cd\u8981\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u81ea\u566c\u7f3a\u9677\u8207\u67d0\u4e9b\u75c5\u7406\u72c0\u614b\u76f8\u95dc\uff0c\u5982\u8001\u5316\u76f8\u95dc\u75be\u75c5\u548c\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff08\u5305\u62ec\u5e15\u91d1\u68ee\u75c5\u548c\u963f\u8332\u6d77\u9ed8\u75c7\uff09\uff0c\u9019\u4e9b\u75be\u75c5\u7684\u7279\u5fb5\u4e4b\u4e00\u662f\u7c92\u7dda\u9ad4\u529f\u80fd\u7570\u5e38\u3002\u89c0\u5bdf\u986f\u793a\uff0c\u7576\u7c92\u7dda\u9ad4\u81ea\u566c\u529f\u80fd\u53d7\u640d\u6642\uff0c\u53ef\u80fd\u6703\u5c0e\u81f4\u4ee5\u7c92\u7dda\u9ad4\u529f\u80fd\u7570\u5e38\u70ba\u7279\u5fb5\u7684\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u767c\u5c55\u3002\u56e0\u6b64\uff0c\u901a\u904e\u7c92\u7dda\u9ad4\u81ea\u566c\u964d\u89e3\u53bb\u9664\u4e0d\u9700\u8981\u6216\u640d\u58de\u7684\u7c92\u7dda\u9ad4\uff0c\u53ef\u80fd\u5c0d\u7dad\u6301\u6709\u6a5f\u9ad4\u5065\u5eb7\u548c\u9810\u9632\u5e74\u9f61\u76f8\u95dc\u7684\u75c5\u7406\u8b8a\u5316\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u200b\u7c92\u7dda\u9ad4\u81ea\u566c\u904e\u53bb\u4e00\u76f4\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u4fc3\u9032\u9577\u58fd\u7684\u6a5f\u5236\u3002\u5148\u524d\u5728\u79c0\u9e97\u96b1\u687f\u7dda\u87f2\uff08C. elegans\uff09\u4e2d\u7684\u7814\u7a76\u8868\u660e\uff0cPDR-1\uff08\u4e00\u7a2eParkin\u540c\u6e90\u7269\uff09\u3001PINK-1\uff08\u4e00\u7a2ePINK1\u540c\u6e90\u7269\uff09\u7684\u6572\u9664\u6703\u964d\u4f4e\u9577\u58fd\u7a81\u8b8a\u682a\u52d5\u7269\u7684\u58fd\u547d\u3002\u9019\u4e9b\u7814\u7a76\u8868\u660eParkin\u3001PINK1\u53c3\u8207\u58fd\u547d\u8abf\u7bc0\u3002\u7136\u800c\uff0c\u6211\u5011\u7121\u6cd5\u5f97\u51fa\u660e\u78ba\u7d50\u8ad6\u662f\u5426\u9019\u4e9b\u86cb\u767d\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u529f\u80fd\u662f\u58fd\u547d\u8abf\u7bc0\u6240\u5fc5\u9700\u7684\u3002\u9664\u4e86\u8abf\u63a7\u7c92\u7dda\u9ad4\u81ea\u566c\uff0cParkin\u548cPINK1\u9084\u5728\u5176\u4ed6\u7d30\u80de\u9014\u5f91\u4e2d\u5177\u6709\u529f\u80fd\u3002\u56e0\u6b64\u96e3\u4ee5\u6e96\u78ba\u5340\u5206PINK1\u548cParkin\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u529f\u80fd\u8207\u5176\u4ed6\u7c92\u7dda\u9ad4\u529f\u80fd\u5c0d\u65bc\u8001\u5316\u6240\u626e\u6f14\u7684\u4f5c\u7528\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u4ee5\u4e00\u822c\u907a\u50b3\u5b78\u529f\u80fd\u7f3a\u5931\uff08genetic loss-of-function\uff09\u7814\u7a76\uff0c\u76ee\u524d\u7121\u6cd5\u76f4\u63a5\u8b49\u5be6\u7c92\u7dda\u9ad4\u81ea\u566c\u4f5c\u70ba\u4fc3\u9032\u9577\u58fd\u6a5f\u5236\u7684\u5047\u8a2d\u3002\u200b<\/p>\n\n\n\n

\u57fa\u65bc\u6700\u8fd1\u767c\u73fe\u7684\u7c92\u7dda\u9ad4\u5167\u819c\u81ea\u566c\u53d7\u9ad4 PHB2\uff0c\u6211\u5011\u5229\u7528\u200b\u9ede\u7a81\u8b8a\u6539\u8b8aPHB2\u7684LIR\u5340\u57df\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u3002\u8a72\u7a81\u8b8a\u6703\u963b\u65b7\u7c92\u7dda\u9ad4\u81ea\u566c\uff0c\u4f46\u4e0d\u5f71\u97ffPHB2\u7684\u5176\u4ed6\u7c92\u7dda\u9ad4\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u6211\u5011\u53ef\u4ee5\u4f7f\u7528PHB2\u7684LIR\u7a81\u8b8a\u682a\u5c07PHB2\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u529f\u80fd\u8207\u5176\u4ed6PHB2\u7684\u7c92\u7dda\u9ad4\u529f\u80fd\u5206\u958b\u3002\u4f7f\u6211\u5011\u80fd\u5920\u63a1\u7528\u7368\u7279\u7684\u907a\u50b3\u5b78\u65b9\u6cd5\uff0c\u66f4\u52a0\u7cbe\u78ba\u5730\u89c0\u5bdf\u7c92\u7dda\u9ad4\u81ea\u566c\u662f\u5426\u70ba\u4e00\u7a2e\u4fc3\u9032\u9577\u58fd\u7684\u6a5f\u5236\uff0c\u751a\u81f3\u7814\u7a76\u7c92\u7dda\u9ad4\u81ea\u566c\u5728\u5176\u4ed6\u4ee3\u8b1d\u6216\u751f\u7406\u529f\u80fd\u7684\u4f5c\u7528\u3002\u6211\u5011\u76ee\u524d\u5728Phb2 LIR\u7a81\u8b8a\u5c0f\u9f20\u4e0a\u767c\u73fe\u4e86\u7279\u5b9a\u4ee3\u8b1d\u8207\u795e\u7d93\u9000\u5316\u75be\u75c5\u7684\u7279\u5fb5\uff0c\u4ee3\u8868\u7c92\u7dda\u9ad4\u81ea\u566c\u7684\u7f3a\u5931\u6703\u5c0e\u81f4\u9019\u4e9b\u75c5\u7406\u73fe\u8c61\u7684\u767c\u5c55\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7814\u7a76\u65b9\u5411\u4e8c\uff1a\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\u7684\u9a45\u52d5\u529b\uff08Driving force of OMM rupture during mitophagy<\/strong>\uff09<\/h2>\n\n\n\n

\u7c92\u7dda\u9ad4\u81ea\u566c\u904e\u7a0b\u4e2d\u6703\u767c\u751f\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\uff0c\u66b4\u9732\u51fa\u5167\u819c\u7684\u7d44\u6210\u7269\uff0c\u4e26\u88ab\u7d30\u80de\u8cea\u767c\u751f\u7684\u81ea\u566c\u4f5c\u7528\u8b58\u5225\u3002\u9019\u500b\u6a5f\u5236\u5c0d\u7c92\u7dda\u9ad4\u81ea\u566c\u4f86\u8aaa\u662f\u4e00\u500b\u91cd\u8981\u7684\u904e\u7a0b\u3002\u9019\u4ef6\u4e8b\u7684\u767c\u751f\u4e26\u4e0d\u662f\u55ae\u7d14\u5730\u56e0\u70ba\u7c92\u7dda\u9ad4\u56e0\u640d\u58de\u800c\u74e6\u89e3\uff0c\u800c\u662f\u900f\u904e\u7279\u5b9a\u9014\u5f91\u8abf\u63a7\u7684\u73fe\u8c61\u3002\u76ee\u524d\u5df2\u77e5\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\u9700\u8981Parkin\u4ee5\u53ca\u86cb\u767d\u9176\u9ad4\uff08Proteasome\uff09\u7684\u4f5c\u7528\u3002\u4f46\u662f\u5177\u9ad4\u5916\u819c\u7684\u662f\u5982\u4f55\u5931\u53bb\u5b83\u7684\u6b63\u5e38\u7d50\u69cb\u7684? \u6211\u5011\u5c0d\u65bc\u65bc\u9019\u65b9\u9762\u7684\u4e86\u89e3\u5e7e\u4e4e\u5168\u7121\u3002<\/p>\n\n\n\n

\u8981\u89e3\u6c7a\u9019\u500b\u554f\u984c\uff0c\u9996\u5148\u5fc5\u9808\u8981\u6709\u4e00\u500b\u65b9\u4fbf\u7684\u5de5\u5177\u53ef\u4ee5\u6709\u6548\u6e2c\u91cf\u7c92\u7dda\u9ad4\u5916\u819c\u7684\u7834\u88c2\u3002\u5728\u904e\u5f80\uff0c\u86cb\u767d\u9176\u4fdd\u8b77\u6e2c\u5b9a\u6cd5\uff08Protease protection assay\uff09\u8207\u7a7f\u900f\u5f0f\u96fb\u5b50\u986f\u5fae\u93e1\uff08TEM\uff09\u5e38\u88ab\u7528\u4f86\u63a2\u6e2c\u819c\u7834\u88c2\uff0c\u4f46\u9019\u4e9b\u65b9\u6cd5\u64cd\u4f5c\u975e\u5e38\u8017\u6642\u4e14\u9700\u8981\u56b4\u683c\u512a\u5316\uff0c\u9650\u5236\u4e86\u5176\u9ad8\u901a\u91cf\u7684\u61c9\u7528\u6027\u3002\u70ba\u61c9\u5c0d\u6b64\u6311\u6230\uff0c\u6211\u5011\u958b\u767c\u4e86\u4e00\u7a2e\u5075\u6e2c\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\u7684\u751f\u7269\u611f\u61c9\u5668\uff08biosensor\uff09\uff0c\u5229\u7528\u5c0f\u5206\u5b50\u8a98\u5c0e\u87a2\u5149\u86cb\u767d\u611f\u61c9\u5206\u5b50\u7684\u805a\u96c6\u4f86\u76f4\u63a5\u5075\u6e2c\u5916\u819c\u7834\u88c2\u4f4d\u9ede\u3002\u8a72\u65b9\u6cd5\u53ef\u5728\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\u8655\u5f62\u6210\u660e\u986f\u7684\u9ede\u72c0\u8a0a\u865f\uff0c\u4e26\u53ef\u5728\u986f\u5fae\u93e1\u4e0b\u5feb\u901f\u7684\u9032\u884c\u5075\u6e2c\u3001\u7d71\u8a08\u8207\u5206\u6790\u3002\u6211\u5011\u7528\u9019\u500b\u65b0\u5de5\u5177\u91cd\u65b0\u9a57\u8b49\u4e86\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\u9700\u8981\u86cb\u767d\u9176\u9ad4\u548cParkin\u7684\u6d3b\u6027\uff0c\u4e26\u63a1\u7528\u8f03\u9ad8\u901a\u91cf\u7684\u907a\u50b3\u548c\u85e5\u7406\u6a21\u5f0f\u4f86\u7814\u7a76\u7c92\u7dda\u9ad4\u5916\u819c\u7834\u88c2\u7684\u76f8\u95dc\u5206\u5b50\u6a5f\u5236\uff0c\u63ed\u793a\u5728\u7d30\u80de\u4e2d\u7684\u7279\u5b9a\u5206\u5b50\u53c3\u8207\u5176\u4e2d\u7684\u5916\u819c\u7834\u88c2\u904e\u7a0b\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7814\u7a76\u65b9\u5411\u4e09\uff1a\u819c\u901a\u900f\u6027\u611f\u61c9\u5668\u7684\u767c\u5c55\uff08Development of biosensor for membrane permeabilization<\/strong>\uff09<\/h2>\n\n\n\n

\u5728\u7d30\u80de\u5167\uff0c\u819c\u7684\u901a\u900f\u6027\u6539\u8b8a\u5c0d\u65bc\u7d30\u80de\u4f86\u8aaa\u662f\u4e00\u4ef6\u5927\u4e8b\uff0c\u5b83\u53ef\u4ee5\u662f\u8abf\u63a7\u7d30\u80de\u529f\u80fd\u7684\u6b63\u5e38\u6a5f\u5236\uff0c\u4f46\u4e5f\u53ef\u4ee5\u4ee3\u8868\u5371\u96aa\u6216\u662f\u6b7b\u4ea1\u7684\u8a0a\u865f\u3002\u56e0\u6b64\u6709\u6548\u7684\u5075\u6e2c\u819c\u7684\u901a\u900f\u6027\u6539\u8b8a\u53ef\u4ee5\u5e6b\u52a9\u6211\u5011\u4e86\u89e3\u7d30\u80de\u7a69\u614b\uff08cellular homeostasis\uff09\u6216\u662f\u58d3\u529b\u53cd\u61c9\uff08stress response\uff09\u7684\u8abf\u63a7\u6a5f\u5236\u3002 <\/p>\n\n\n\n

\u76ee\u524d\u6211\u5011\u4ecd\u5728\u4f7f\u7528\u4e0d\u540c\u65b0\u6280\u8853\u7684\u7d44\u5408\uff0c\u91dd\u5c0d\u4e0a\u8ff0\u819c\u7834\u88c2\u611f\u61c9\u5668\u9032\u884c\u66f4\u9032\u4e00\u6b65\u7684\u6539\u826f\uff0c\u4ee5\u671f\u80fd\u4ee5\u66f4\u9ad8\u654f\u611f\u5ea6\u5728\u6d3b\u7d30\u80de\u5167\u5373\u6642\u5075\u6e2c\u7c92\u7dda\u9ad4\u3001\u6216\u662f\u5176\u4ed6\u80de\u5668\u819c\u7834\u88c2\u7684\u767c\u751f\u3002\u9577\u9060\u4f86\u8aaa\uff0c\u672a\u4f86\u9019\u6a23\u7684\u5de5\u5177\u5c07\u53ef\u4ee5\u89e3\u6c7a\u7576\u4eca\u5075\u6e2c\u80de\u5668\u901a\u900f\u6027\u7684\u6280\u8853\u554f\u984c\uff0c\u66f4\u5ee3\u6cdb\u7684\u904b\u7528\u5728\u5075\u6e2c\u8207\u819c\u901a\u900f\u6027\u76f8\u95dc\u7684\u7d30\u80de\u751f\u7269\u5b78\u7814\u7a76\u4e0a\u3002<\/p>\n\n\n\n

Macroautophagy (hereafter referred to as autophagy) is a catabolic pathway by which cells sequester unwanted or damaged cellular proteins or organelles through a double membrane structure called the autophagosome. This process is mediated by a set of evolutionarily conserved genes, the autophagy-related (ATG) genes, which function in nucleation of the autophagosomal membrane, elongation of the autophagic membrane, sequestration of cytoplasmic constituents, and lysosomal degradation of the sequestered contents.<\/p>\n\n\n\n

Selective autophagy is a homeostatic quality control process that targets specific cytoplasmic components to autophagosomes for lysosomal destruction. Diverse cargos have been identified as substrates for selective autophagy, including mitochondria (mitophagy), peroxisomes (pexophagy), endoplasmic reticulum (ERophagy), and viruses (virophagy). Mitophagy is the major pathway by which eukaryotic cells eliminate damaged or unwanted mitochondria as damaged mitochondria release reactive oxygen species (ROS), leading to inflammasome activation, genotoxic stress, promotion of tumorigenesis and aging. Defects in mitophagy are implicated in neurodegenerative diseases such as Parkinson\u2019s disease, Alzheimer disease, and age-related pathologies. Thus, the proper removal of mitochondria is essential for organismal health in diverse eukaryotic species.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

The primary research focus of our laboratory is to understand the molecular regulation and biological functions of mitophagy. A fundamental question in the autophagy field remains how cargos such as mitochondria are selectively targeted for autophagic degradation. We will use series of genetic, cell biology, biochemical approaches to understand the mechanisms that confer substrate selectivity<\/strong> in mitophagy and investigate the pathological consequences of mitophagy dysfunction in diseases<\/strong> using model organisms such as C. elegans and mice. These studies may guide future efforts in developing therapeutic options against age-related and neurodegenerative diseases and pave the way for the development of new treatments for patients with diseases associated with mitochondrial dysfunction.<\/p>\n\n\n\n

\u7814\u7a76\u8457\u4f5c<\/h1>\n\n\n\n

Wei-Hua Chu*, Yu-Shan Lin*, Jing Guo*, Wann-Neng Jane, Won-Jing Wang, Yu-Yang Lin, Pei-Han Liu, Po-Yu Huang, Wei-Chung Chiang<\/u>. The ubiquitin-binding protein ANKRD13A mediates VCP-dependent mitochondrial outer membrane rupture during PINK1\/Parkin-mediated mitophagy.<\/mark> J. Biol. Chem. DOI: 10.1016\/j.jbc.2025.110739 (2025) (In press) <\/em>(Featured article in \u201cEditor\u2019s Pick\u201d)<\/mark><\/p>\n\n\n\n

Pei-Han Liu, Yu-Shan Lin, Wei-Hua Chu, Wei-Tze Sun, Po-Yu Huang, Jie-Rong Huang, Wei-Chung Chiang<\/u>. Galectin-3 Directs Mitophagy in Response to Parkin-\/Proteasome-Dependent Rupture of Mitochondrial Outer Membrane.<\/mark> Biol. Direct. (2025) (In press)<\/em><\/p>\n\n\n\n

Xiaonan Dong, Qiren Liang, Yun-Zu Pan, Xiaoyu Wang, Yi-Chun Kuo, Wei-Chung Chiang<\/u>, Xuewu Zhang, Noelle S. Williams, Josep Rizo, Beth Levine, and Jef K. De Brabander; Novel Bcl\u20112 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2\u2212Beclin 1 Protein\u2212Protein Interaction.<\/span> ACS Med. Chem. Lett.,13: 1510\u22121516 (2022)<\/em><\/p>\n\n\n\n

Jing Guo and Wei-Chung Chiang*<\/u>. Mitophagy in Aging and Longevity<\/span>. IUBMB Life, 74(4):296-316 (2022)<\/em><\/p>\n\n\n\n

\u00c1lvaro F. Fern\u00e1ndez, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn McMillan, Congcong He, Tabitha Ting, Yang Liu, Wei-Chung Chiang<\/u>, Denise Marciano, Gabriele Schiatarella, Govind Bhagat, Orson W. Moe, Ming-Chang Hu and Beth Levine. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.Disruption of the beclin 1\/Bcl-2 autophagy regulatory complex promotes longevity in mice.<\/span> Nature. 558 (7708) 136-140 (2018).<\/em><\/p>\n\n\n\n

Wei-Chung Chiang<\/u>, Yongjie Wei, Yi-Chun Kuo, Shuguang Wei, Anwu Zhou, Zhongju Zou, Jenna Yehl, Matthew J. Ranaghan, Adam Skepner, Joshua A. Bittker, Jose R. Perez, Bruce A. Posner and Beth Levine. High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1\/Bcl-2 Binding.<\/span> ACS Chem Biol. (2018). doi: 10.1021\/acschembio.8b00421.<\/em><\/p>\n\n\n\n

Yongjie Wei*, Wei-Chung Chiang*<\/u>, Rhea Sumpter Jr., Prashant Mishra and Beth Levine. Prohibitin 2 is an Inner Mitochondrial Membrane Mitophagy Receptor. <\/span>Cell. 168(1-2) 224-238 (2017). (*co-first author)<\/em><\/p>\n\n\n\n

Wei-Chung Chiang<\/u>, Tsui-Ting Ching, Hee-Chul Lee, Carol Mousigian and Ao-Llin Hsu. HSF-1 regulators DDL-1\/2 link insulin-like signaling to heat-shock responses and modulation of longevity.<\/span> Cell. 148(1) 322-334 (2012).<\/em><\/p>\n\n\n\n

Wei-Chung Chiang<\/u>, Daniel X. Tishkoff, Bo Yang, Joshua Wilson-Grady, Xiaokun Yu, Travis Mazer, Mark Eckersdorff, Steven P. Gygi, David B. Lombard, and Ao-Lin Hsu. C. elegans SIRT6\/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress.<\/span> PLoS Genetics, 8(9): e1002948.<\/em><\/p>\n\n\n\n

Tsui-Ting Ching, Wei-Chung Chiang<\/u>, Ching-Shih Chen and Ao-Lin Hsu. Celecoxib Extends Worm Lifespan Independent of COX-2 Inhibition. Aging Cell.<\/em><\/span> 10(3):506-19 (2010).<\/em><\/p>\n\n\n\n

Mu-Hwa Yang, Wei-Chung Chiang<\/u>, Shyue-Yih Chang, Po-Min Chen and Kou-Juey Wu. Increased NBS1 expression as a prognostic marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation.<\/span> Clin. Cancer Res. 12, 507-515 (2006).<\/em><\/p>\n\n\n\n

Yen-Chung Chen, Yi-Ning Su, Po-Chien Chou, Wei-Chung Chiang<\/u>, Ming-Cheng Chang, Liang-Shun Wang, Shu-Chun Teng and Kou-Juey Wu. Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase\/Akt.<\/span> J. Biol. Chem. 280, 32505-11 (2005).<\/em><\/p>\n\n\n\n

Shih-Hung Yu, Wei-Chung Chiang<\/u>, Hsiu-Ming Shih and Kou-Juey Wu. Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta.<\/span> J. Mol. Med. 82(9):621-8 (2004).<\/em><\/p>","protected":false},"excerpt":{"rendered":"

\u5c08\u9577–\u7d30\u80de\u81ea\u566c\u7814\u7a76\u3001\u7c92\u7dda\u9ad4\u751f\u7269\u5b78\u3001 \u8001\u5316\u751f\u7269\u5b78\u3001\u7d30\u80de\u81ea\u566c\u8a98\u5c0e\u85e5\u7269\u3001\u9ad8\u901a\u91cf\u85e5\u7269\u7be9\u9078<\/p>","protected":false},"author":2,"featured_media":583,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-559","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-full-time","entry","has-media"],"_links":{"self":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/posts\/559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/comments?post=559"}],"version-history":[{"count":0,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/posts\/559\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/media\/583"}],"wp:attachment":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/media?parent=559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/categories?post=559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/tags?post=559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}