{"id":560,"date":"2025-10-28T13:48:47","date_gmt":"2025-10-28T05:48:47","guid":{"rendered":"https:\/\/biochem.nycu.edu.tw\/%e5%bc%b5%e5%b4%87%e5%be%b7\/"},"modified":"2026-02-05T10:50:26","modified_gmt":"2026-02-05T02:50:26","slug":"changchung-te","status":"publish","type":"post","link":"https:\/\/biochem.nycu.edu.tw\/english\/faculty\/full-time\/changchung-te\/","title":{"rendered":"\u5f35\u5d07\u5fb7 \u526f\u6559\u6388"},"content":{"rendered":"\n
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\u5c08\u9577<\/mark>
RNA Biology\u3001miRNA\u8abf\u63a7\u6a5f\u5236\u3001mRNA\u964d\u89e3\u6a5f\u5236 <\/h2>\n\n\n\n

\u8fa6\u516c\u5ba4<\/mark>
\u751f\u7269\u91ab\u5b78\u5927\u6a13 \u4e94\u6a13 R505 \u5ba4<\/h2>\n\n\n\n

\u96fb\u8a71<\/mark>
886-2-2826-7122<\/h2>\n\n\n\n

Email<\/mark>
chungte.chang@nycu.edu.tw<\/a><\/h2>\n\n\n\n

\u500b\u4eba\u7db2\u9801<\/mark>
https:\/\/sites.google.com\/view\/chungte-chang<\/a><\/h2>\n\n\n\n

ORCiD<\/mark>
0000-0002-4792-1646<\/a><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\u5b78\u7d93\u6b77<\/h1>\n\n\n\n
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2026 \u8fc4\u4eca
2021-2026
2019-2021
2012-2019
2008-2012<\/p>\n<\/div>\n\n\n\n

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\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u751f\u5316\u66a8\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240 \u526f\u6559\u6388
\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u751f\u5316\u66a8\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240 \u52a9\u7406\u6559\u6388
\u570b\u7acb\u967d\u660e\u5927\u5b78 \u751f\u5316\u66a8\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240 \u52a9\u7406\u6559\u6388
\u5fb7\u570b \u99ac\u514b\u65af\u666e\u6717\u514b\u767c\u80b2\u751f\u7269\u5b78\u7814\u7a76\u6240 \u535a\u58eb\u5f8c\u7814\u7a76\u54e1
\u82f1\u570b \u96ea\u83f2\u723e\u5927\u5b78 \u535a\u58eb<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u69ae\u8b7d<\/h1>\n\n\n\n
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2022
2021
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2020
2019<\/p>\n<\/div>\n\n\n\n

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\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u751f\u547d\u79d1\u5b78\u9662\u7279\u6b8a\u512a\u79c0\u6559\u7814\u4eba\u54e1\u734e\u52f5 \u65b0\u8058\u7279\u6b8a\u512a\u79c0\u6559\u7814\u4eba\u54e1
\u8ca1\u5718\u6cd5\u4eba\u6c88\u529b\u63da\u6559\u6388\u91ab\u5b78\u6559\u80b2\u734e\u5b78\u7d00\u5ff5\u57fa\u91d1\u6703 \u8b1b\u5e2b\u7d1a\u7814\u7a76\u8207\u9032\u4fee\u734e\u52a9
\u570b\u7acb\u967d\u660e\u5927\u5b78\u826f\u5e2b\u76ca\u53cb\u5c0e\u5e2b
\u570b\u7acb\u967d\u660e\u5927\u5b78\u826f\u5e2b\u76ca\u53cb\u5c0e\u5e2b
\u79d1\u6280\u90e8\u88dc\u52a9\u5927\u5c08\u6821\u9662\u5ef6\u652c\u7279\u6b8a\u512a\u79c0\u4eba\u624d<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u6307\u5c0e\u5b78\u751f\u7372\u734e<\/h1>\n\n\n\n
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2025
2024
2024
2023<\/p>\n<\/div>\n\n\n\n

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\u78a9\u58eb\u751f \u77f3\u8a60\u6df3 \u751f\u5316\u6240\u5c39\u73e3\u82e5\u8ad6\u6587\u6bd4\u8cfd \u7b2c\u4e09\u540d
\u78a9\u58eb\u751f \u912d\u5b87\u73b9 \u5c39\u73e3\u82e5\u54c1\u5b78\u53ca\u8ad6\u6587\u512a\u826f\u66a8\u967d\u660e\u4ea4\u901a\u5927\u5b78\u78a9\u58eb\u73ed\u512a\u826f\u8ad6\u6587\u734e\u5b78\u91d1 \u512a\u7b49\u734e
\u78a9\u58eb\u751f \u912d\u5b87\u73b9 \u751f\u5316\u6240\u5c39\u73e3\u82e5\u8ad6\u6587\u6bd4\u8cfd \u7b2c\u4e00\u540d
\u78a9\u58eb\u751f \u6797\u54c1\u7504 \u751f\u5316\u6240\u5c39\u73e3\u82e5\u8ad6\u6587\u6bd4\u8cfd \u7b2c\u4e09\u540d<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u7814\u7a76\u65b9\u5411<\/h1>\n\n\n\n

\u96a8\u8457RNA\u6c89\u9ed8\u8def\u5f91\u7684\u767c\u73fe\u4ee5\u53ca\u5f8c\u8f49\u9304\u8abf\u63a7\u7684\u91cd\u8981\u6027\u9010\u6f38\u88ab\u63ed\u793a\uff0c\u57fa\u56e0\u8868\u9054\u7684\u8abf\u63a7\u5df2\u4e0d\u518d\u50c5\u50c5\u5c40\u9650\u65bc\u8f49\u9304\u5c64\u9762\uff0c\u6211\u5011\u8fce\u4f86\u4e86\u57fa\u56e0\u8868\u9054\u7814\u7a76\u7684\u65b0\u7d00\u5143\u3002\u5728\u9019\u500b\u5d84\u65b0\u7684\u9818\u57df\u4e2d\uff0cmRNA\u7684\u52a0\u5de5\u3001\u8f38\u51fa\u3001\u76e3\u63a7\u3001\u6c89\u9ed8\u548c\u964d\u89e3\u7b49\u904e\u7a0b\u5171\u540c\u7d44\u6210\u4e86\u4e00\u500b\u7cbe\u5bc6\u7684\u8abf\u63a7\u7db2\u7d61\uff0c\u6df1\u523b\u5f71\u97ff\u8457\u7d30\u80de\u548c\u751f\u7269\u9ad4\u7684\u57fa\u56e0\u8868\u9054\u6a21\u5f0f\u3002<\/p>\n\n\n\n

\u5728mRNA\u7684\u751f\u547d\u9031\u671f\u5167\uff0c\u5b83\u4ee5\u6838\u7cd6\u6838\u86cb\u767d\u9846\u7c92(mRNP)\u7684\u5f62\u5f0f\u5b58\u5728\uff0c\u70ba\u773e\u591a\u86cb\u767d\u8cea\u7684\u7d50\u5408\u63d0\u4f9b\u4e86\u7406\u60f3\u5e73\u53f0\uff0c\u5728\u5f8c\u8f49\u9304\u9014\u5f91\u7684\u4e0d\u540c\u6b65\u9a5f\u4e2d\u626e\u6f14\u8457\u95dc\u9375\u89d2\u8272\u3002\u4ee4\u4eba\u9a5a\u5947\u7684\u662f\uff0c\u53c3\u8207mRNA\u964d\u89e3\u3001\u76e3\u63a7\u3001RNA\u6c89\u9ed8\u53ca\u8f49\u8b6f\u6291\u5236\u7684\u86cb\u767d\u8cea\uff0c\u7d93\u5e38\u5171\u5b9a\u4f4d\u65bcmRNA\u8655\u7406\u9ad4(P-body)\u4e2d\uff0c\u986f\u793a\u9019\u4e9b\u904e\u7a0b\u5f7c\u6b64\u7dca\u5bc6\u76f8\u9023\uff0c\u800c\u9019\u4e9b\u86cb\u767d\u7684\u7570\u5e38\u6703\u5c0e\u81f4\u591a\u7a2e\u4eba\u985e\u91cd\u8981\u75be\u75c5\uff0c\u5305\u62ec\u764c\u75c7\u548c\u5148\u5929\u6027\u514d\u75ab\u7570\u5e38\uff1b\u7136\u800c\uff0c\u5176\u8a73\u7d30\u7684\u8abf\u63a7\u6a5f\u5236\u537b\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n\n\n\n

\u6211\u5011\u7684\u7814\u7a76\u76ee\u6a19\u662f\u89e3\u958b\u5f8c\u8f49\u9304\u5c64\u9762\u8abf\u63a7\u6a5f\u5236\u7684\u795e\u79d8\u9762\u7d17\uff0c\u4e26\u5c07\u9019\u4e9b\u767c\u73fe\u61c9\u7528\u65bc\u75be\u75c5\u6cbb\u7642\u4e2d\u3002\u901a\u904e\u7d30\u80de\u5be6\u9a57\u8207\u529f\u80fd\u57fa\u56e0\u7d44\u5b78\u7684\u7d50\u5408\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63ed\u793a\u5f8c\u8f49\u9304\u904e\u7a0b\u4e4b\u9593\u7684\u8907\u96dc\u95dc\u4fc2\u53ca\u5176\u5c0d\u57fa\u56e0\u8868\u9054\u7684\u6df1\u9060\u5f71\u97ff\uff0c\u6df1\u5165\u7406\u89e3\u5b83\u5011\u8207\u4e0d\u540c\u7d30\u80de\u9032\u7a0b\u9593\u7684\u806f\u7e6b\uff0c\u4e26\u9396\u5b9a\u5167\u6e90\u6027\u76ee\u6a19\uff0c\u5f9e\u800c\u95e1\u660e\u9019\u4e9b\u9014\u5f91\u53d7\u5230\u5e72\u64fe\u6642\u6240\u5f15\u767c\u7684\u8907\u96dc\u7d30\u80de\u548c\u751f\u7269\u9ad4\u8868\u578b\u3002\u9019\u4e9b\u7814\u7a76\u4e0d\u50c5\u50c5\u589e\u9032\u4e86\u6211\u5011\u5c0d\u57fa\u56e0\u8868\u9054\u8abf\u63a7\u7684\u7406\u89e3\uff0c\u66f4\u70ba\u8a31\u591a\u91cd\u5927\u75be\u75c5\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5d84\u65b0\u7684\u601d\u8def\u3002\u76ee\u524d\uff0c\u6211\u5011\u6b63\u5728\u63a2\u7d22\u5982\u4f55\u91dd\u5c0d\u7279\u5b9a\u7684RNA\u7d50\u5408\u86cb\u767d\u958b\u767c\u65b0\u578b\u6297\u764c\u6a5f\u5236\uff0c\u4ee5\u53ca\u901a\u904e\u8abf\u63a7\u5f8c\u8f49\u9304\u9014\u5f91\u4f86\u62b5\u79a6\u75c5\u6bd2\u611f\u67d3\uff0c\u5e0c\u671b\u80fd\u5920\u627e\u5230\u6cbb\u7642\u764c\u75c7\u548c\u75c5\u6bd2\u611f\u67d3\u7684\u5168\u65b0\u7b56\u7565\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n\n\n\n

\u7814\u7a76\u8457\u4f5c<\/h1>\n\n\n\n

Lin YQ, Shih YC, Chang CT<\/u>. (2025) Plasmid DNA Purification Using Filterprep With an Optional Endotoxin Removal Step. <\/mark>Bio-protocol 15:e5547<\/em><\/p>\n\n\n\n

Cheng YH, Wu YJ, Shih YC, Lin YQ, Chang YW, Wu YH, Hu EW, Ku RH, Wu CM, Wu SC, Yeh TY, Chang CT*<\/u>. (2025) The Filterprep: A simple and efficient approach for high-yield, high-purity plasmid DNA purification.<\/span> New Biotechnology 90:77-87<\/em><\/p>\n\n\n\n

Chiu HS*, Somvanshi S*, Chang CT*<\/u>, de Bony de Lavergne EJ, Wei Z, Hsieh CH, Trypsteen W, Scorsone KA, Patel E, Tang TT, Flint DB, Najaf Panah MJ, Kim HR, Rathi P, Lee YW, Woodfield SE, Vasudevan SA, Heczey AA, Gaber MW, Sawakuchi GO, Chen TW, Mestdagh P, Yang X, Sumazin P. (2025) Coordinated regulation by lncRNAs results in tight lncRNA-target couplings.<\/span>Cell Genom. 5:100927. <\/em>(*co-first) \u25ba Journal cover article<\/p>\n\n\n\n

Chang CT*<\/u>, Chiang CK*, Chen KY, Cheng YH, Chiu HH, Shen YJ, Liao HW. (2025) Development of a Novel TRIzol-like Reagent for Sequential Extraction of Biomolecules to Facilitate Multiomics Studies.<\/span> Microchem. J. 215:114371. <\/em>(*co-first)<\/p>\n\n\n\n

Cheng YH, Chen TW, Chiang WC, Kuo JC, Ho YS, Noble M, Chang CT<\/u>. (2025) EDC4 C-terminal domain scaffolds P-body assembly and links P-body dynamics to p53-mediated tumor suppression.<\/span> RNA 31:1176-1194.<\/em><\/p>\n\n\n\n

\n\nChen TW, Liao HW, Noble M, Siao JY, Lo YT, Chang CT<\/u>. (2024) Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions. <\/span> eLife. (Reviewed Preprint) <\/em><\/p>\n\n\n\n

\n\nWeber R, Chang CT<\/u>. (2024) Human DDX6 regulates translation and decay of inefficiently translated mRNAs. <\/span> eLife. 13:RP92426. <\/em><\/p>\n\n\n\n

\n\nChang CT<\/u>. (2024) Analysis of Human Endogenous mRNA Deadenylation Complexes by High-Resolution Gel Electrophoresis. <\/span> Methods Mol Biol. 2723:47-54. <\/em><\/p>\n\n\n\n

\n\nKao CY, Chang CT<\/u>, Kuo PY, Lin CJ, Chiu HH, Liao HW. (2023) Sequential isolation of metabolites and lipids from a single sample to achieve multiomics by using TRIzol reagent. <\/span> Talanta. 258:124416. <\/em><\/p>\n\n\n\n

Enwerem III, Elrod ND, Chang CT<\/u>, Lin A, Ji P, Bohn JA, Levdansky Y, Wagner EJ, Valkov E, Goldstrohm AC. (2021) Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.<\/span> RNA. 27:445-464.<\/em><\/p>\n\n\n\n

Arvola RM, Chang CT<\/u>, Buytendorp JP, Levdansky Y, Valkov E, Freddolino PL, Goldstrohm AC. (2020) Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs.<\/span> Nucleic Acids Res. 48:1843-1871.<\/em><\/p>\n\n\n\n

Hanet A, R\u00e4sch F, Weber R, Ruscica V, Fauser M, Raisch T, Kuzuo\u011flu-\u00d6zt\u00fcrk D, Chang CT<\/u>, Bhandari D, Igreja C, Wohlbold L. (2019) HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs.<\/span> Life Sci Alliance. 2:e201900405.<\/em><\/p>\n\n\n\n

Chang CT<\/u>, Muthukumar S, Weber R, Levdansky Y, Chen Y, Bhandari D, Igreja C, Wohlbold L, Valkov E, Izaurralde E. (2019) A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′-3′ messenger RNA decay.<\/span> Nucleic Acids Res. <\/em>[Epub ahead of print]<\/p>\n\n\n\n

Raisch T*,Chang CT*<\/u>, Levdansky Y*, Muthukumar S, Raunser S, Valkov E. (2019) Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.<\/span> Nat Commun. 10:3173. <\/em>(*co-first)<\/p>\n\n\n\n

Valkov E*, Muthukumar S*, Chang CT*<\/u>, Jonas S, Weichenrieder O, Izaurralde E. (2016) Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.<\/span> Nat Struct Mol Biol. 23:574-9. <\/em>(*co-first)<\/p>\n\n\n\n

Chen Y, Boland A, Kuzuo\u011flu-\u00d6zt\u00fcrk D, Bawankar P, Loh B, Chang CT<\/u>, Weichenrieder O, Izaurralde E. (2014) A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.<\/span> Mol Cell. 54:737-50.<\/em><\/p>\n\n\n\n

Chang CT<\/u>, Bercovich N, Loh B, Jonas S, Izaurralde E. (2014) The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.<\/span> Nucleic Acids Res. 42:5217-33.<\/em><\/p>\n\n\n\n

Chang CT*<\/u>, Hautbergue GM*, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA. (2013) Chtop is a component of the dynamic TREX mRNA export complex.<\/span> EMBO J. 32:473-86. <\/em>(*co-first)<\/p>\n\n\n\n

Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT<\/u>, Haas G, Weichenrieder O, Coles M, Izaurralde E. (2012) A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation.<\/span> Nat Struct Mol Biol. 19:1324-31.<\/em><\/p>\n\n\n\n

Viphakone N, Hautbergue GM, Walsh M, Chang CT<\/u>, Holland A, Folco EG, Reed R, Wilson SA. (2012) TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.<\/span> Nat Commun. 3:1006.<\/em><\/p>\n\n\n\n

Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT<\/u>, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW. (2011) A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.<\/span> Science. 334:821-4.<\/em><\/p>\n\n\n\n

Hautbergue GM, Hung ML, Walsh MJ, Snijders AP, Chang CT<\/u>, Jones R, Ponting CP, Dickman MJ, Wilson SA. (2009) UIF, a New mRNA export adaptor that works together with REF\/ALY, requires FACT for recruitment to mRNA.<\/span> Curr Biol. 19:1918-24.<\/em><\/p>\n\n\n\n

Su MC, Chang CT<\/u>, Chu CH, Tsai CH, Chang KY. (2005) An atypical RNA pseudoknot stimulator and an upstream attenuation signal for -1 ribosomal frameshifting of SARS coronavirus.<\/span> Nucleic Acids Res. 33:4265-75.<\/em><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5c08\u9577–RNA Biology\u3001miRNA\u8abf\u63a7\u6a5f\u5236\u3001mRNA\u964d\u89e3\u6a5f\u5236<\/p>","protected":false},"author":2,"featured_media":4173,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-560","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-full-time","entry","has-media"],"_links":{"self":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/posts\/560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/comments?post=560"}],"version-history":[{"count":0,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/posts\/560\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/media\/4173"}],"wp:attachment":[{"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/media?parent=560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/categories?post=560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochem.nycu.edu.tw\/english\/wp-json\/wp\/v2\/tags?post=560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}