研究領域

利用多維異核核磁共振技術從結構的觀點探討生物巨分子之功能。「動脈粥狀硬化」和「阿茲海默症」等老年退化性疾病相關的生物巨分子之結構生物學研究，例如載脂蛋白E(apolipoprotein E)與脂質交互作用之機制及β-類澱粉胜肽(β-amyloid peptide)聚集與阿茲海默症致病機制之關係；開發去泛素化酶(Ubiquitin specific protease, USP)之抑制劑，作為癌症藥物之先導化合物；探討磷酸化如何調控蛋白磷酸酶-1(protein phosphatase-1)與其蛋白抑制劑(protein inhibitors)之交互作用。

研究著作(2021-2025)

Chia-Yu Chang, Ti-Lun Hsu, You-Ren Lai, Josephine W. Wu, Steven S.-S. Wang*, Su-Chun How*, Ta-Hsien Lin*, The application of poly (acrylic Acid)-whey protein isolate amyloid Fibril–derived hybrid hydrogels in drug delivery, 2025, Journal of Drug Delivery Science and Technology, 113, 107299. IF: 4.9, 5 yr IF: 5.2, Ranking (Pharmacology & Pharmacy): 38/353, 10.8% (2024 JCR).

You-Ren Lai, Tzu-Ling Ho, Yu-Hsuan Yang, Ta-Hsien Lin*, Steven S.-S. Wang*, Development of sustainable bioplastic films for food packaging using zein protein-derived amyloid fibrils: characterization and functional properties, 2025, International Journal of Biological Macromolecules, 318, 144817. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

Chiao-Yin Sun, Shu-Chun Cheng, Yun-Hsin Wang, Ching-Yuan Huang, Adam Shih-Yuan Lee, Tao-Sheng Li, Ta-Hsien Lin*, Yau-Hung Chen*, Growth Inhibition Activity Assessment of γ-Lactam-Containing Chemicals in Cultured MCF-7 Cells and Xenografted Chick Embryos, 2025, Journal of Biochemical and Molecular Toxicology, 39, e70344. IF: 2.8, 5 yr IF: 3.1, Ranking (Biochemistry & Molecular Biology): 133/320, 41.6% (2024 JCR).

Kuang-Yung Huang, Hui-Chun Yu, Ming-Chi Lu, Hsien-Yu Huang Tseng, Jyun-Jie Shen, Chia-Ying Lin, Pin-Chen Chen, Ya-Ting Shen, Pei-Rong Chung, Hsiao-Kuei Tsai, Si-Ru Zhou, Chia-Lin Wang, Ning-Sheng Lai, Ta-Hsien Lin, Hsien-Bin Huang, Identification of a novel Eps 15 homology domain-containing protein 1 (EHD1) and EHD4-binding motif in phostensin, 2025, Journal of Biochemistry, 177, 297. IF: 1.7, 5 yr IF: 2.1, Ranking (Biochemistry & Molecular Biology): 271/319, 85.0% (2024 JCR).

Adam Shih-Yuan Lee, Ta-Hsien Lin, Yen-Yu Liu, Yun-Hsin Wang, Shu-Chun Cheng, Tao-Sheng Li, Chiao-Yin Sun*, Yau-Hung Chen*, Growth inhibition and toxicity assessments of cis-3,4-diaryl-α-methylene-γ-butyrolactams in cultured human renal cancer cells and zebrafish embryos, 2025, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1869, 130761. IF: 2.2, 5 yr IF: 2.8, Ranking (Biophysics): 57/79, 68.4% (2024 JCR). Co-first authors

Jia-Ling Tu, You-Ren Lai, Chia-Yu Lin, Steven S.-S. Wang*, Ta-Hsien Lin*, Applications of three-dimensional whey protein amyloid fibril-based hybrid aerogels in oil/water separation and emulsion separation, 2024. International Journal of Biological Macromolecules, 283, 137680. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

Ying Kuan, Hsu-Feng Chu, Pang-Hung Hsu, Ta-Hsien Lin, Chun-Hsiang Huang* and Wei-Yi Chen*,Disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site, 2024, International Journal of Biological Macromolecules, 276, 133955. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

You-Ren Lai, Steven S.-S. Wang*, Ta-Hsien Lin*, Using silver nanoparticle-decorated whey protein isolate amyloid fibrils to modify the electrode surface used for electrochemical detection of para-nitrophenol, 2024, International Journal of Biological Macromolecules, 264, 130404. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

Yu-Yuan Yang, You-Ren Lai, Su-Chun How*, Ta-Hsien Lin*, and Steven S.-S. Wang*, Development of two-dimensional amyloid fibril/carboxymethyl cellulose hybrid membranes for effective adsorption of hexavalent chromium, 2024, Journal of Environmental Chemical Engineering, 12, 114134. IF: 7.2, 5 yr IF: 7.6, Ranking (Engineering, Chemical): 25/175, 14.3% (2024 JCR).

Yu-Yuan Yang, You-Ren Lai, Su-Chun How*, Ta-Hsien Lin*, and Steven S.-S. Wang*, Encapsulation with a Complex of Acidic/Alkaline Polysaccharide-Whey Protein Isolate Fibril Bilayer Microcapsules Enhances the Stability of β-carotene under Acidic Environments , 2024, Journal of the Taiwan Institute of Chemical Engineers, 160, 105344. IF: 6.3, 5 yr IF: 5.4, Ranking (Engineering, Chemical): 31/175, 17.7% (2024 JCR).

You-Ren Lai, Chi-Fong Huang, Su-Chun How, Ta-Hsien Lin* and Steven S.-S. Wang*, Using titanium dioxide nanoparticle-deposited whey protein isolate amyloid fibrils to photocatalyze the degradation of methylene blue, 2024, Journal of the Taiwan Institute of Chemical Engineers, 160, 105313. IF: 6.3, 5 yr IF: 5.4, Ranking (Engineering, Chemical): 31/175, 17.7% (2024 JCR).

Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S.-S. Wang*, Shiu-Huey Chou* and Ta-Hsien Lin*, Developing targeted drug delivery carriers for breast cancer using glutathione-sensitive doxorubicin-coupled glycated bovine serum albumin nanoparticles, 2023, International Journal of Biological Macromolecules, 249, 126114. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

You-Ren Lai, Steven S.-S. Wang, Ti-Lun Hsu, Szu-Hui Chou, Su-Chun How* and Ta-Hsien Lin*, Application of Amyloid-Based Hybrid Membranes in Drug Delivery, 2023, Polymers, 15(6), 1444. IF: 4.9, 5 yr IF: 5.2, Ranking (Polymer Science): 19/94, 20.2% (2024 JCR).

You-Ren Lai, Jinn-Tsyy Lai, Steven S.-S. Wang*, Yung-Chih Kuo*, Ta-Hsien Lin*, Silver nanoparticle-deposited whey protein isolate amyloid fibrils as catalysts for the reduction of methylene blue, 2022, International Journal of Biological Macromolecules, 213, 1098-1114. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

Shu-Shun Hsueh, Steven S.-S. Wang, Shu-Han Chen, Chia-Lin Wang, Josephine W. Wu*, Ta-Hsien Lin*, Insights to Human D-Crystallin Unfolding by NMR Spectroscopy and Molecular Dynamics Simulations, 2022, International Journal of Molecular Sciences, 23, 1591. IF: 4.9, 5 yr IF: 5.7, Ranking (Biochemistry & Molecular Biology): 72/319, 22.6% (2024 JCR).

Hsu-Feng Chu, Shu-Chun Cheng, Chiao-Yin Sun, Chi-Yuan Chou, Ta-Hsien Lin*, Wei-Yi Chen*, Structural and Biochemical Characterization of PEDV Papain-like Protease 2, 2022, Journal of virology, 96, e01372-21. IF: 3.8, 5 yr IF: 3.9, Ranking (Virology): 14/42, 33.3% (2024 JCR).

Tai-Jay Chang*, Cheng-Yuan Hsia, Gar-Yang Chau, Liang-Tsai Hsiao, Kuang-Tzu Huanga, Kung-Liang King, Wing-Yiu Lui, Anna F.-Y Li, Chia-Lin Wang, Pin-Hsing Tsai, Yueh Chien, Ta-Hsien Lin*, Characterization of Androgen Receptor Complex Associated Protein (ARCAP) in Hepatocellular Carcinoma and Liver, 2021, Journal of the Chinese Medical Association, 84, 1100-1108. IF: 2.4, 5 yr IF: 2.0, Ranking (Medicine, General & Internal): 78/330, 23.5% (2024 JCR).

Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu6 Ping-Hui Tseng, Greg G. Wang and Wei-Yi Chen, USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer, 2021, Cell Death and Disease, 12:880. IF: 8.1, 5 yr IF: 8.6, Ranking (Cell Biology): 33/205, Q1, 84.1% (2023 JCR).

Su-Chun How, Ta-Hsien Lin*, Chun-Chao Chang*, Steven S.-S. Wang*, Examining the effect of bovine serum albumin on the properties and drug release behavior of β-lactoglobulin-derived amyloid fibril-based hydrogels, 2021, International Journal of Biological Macromolecules, 184, 79-71. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, 6.4% (2024 JCR).

Hsin-Cheng Lin, Ying Kuan, Hsu-Feng Chu, Shu-Chun Cheng, Heng-Chih Pan, Wei-Yi Chen, Chiao-Yin Sun*, Ta-Hsien Lin*, Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21, 2021, International Journal of Biological Macromolecules, 176, 490-497. IF: 8.5, 5 yr IF: 8.7, Ranking (Polymer Science): 6/94, Q1, 6.4% (2024 JCR).

Shu-Shun Hsueh, Jian-Hong Lu, Josephine W. Wu*,Ta-Hsien Lin*, Steven S.-S. Wang*, Protection of human γD-crystallin protein from ultraviolet C-induced aggregation by ortho-vanillin, 2021, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 261, 120023. IF: 4.6, 5 yr IF: 4.3, Ranking (Spectroscopy): 5/44, 11.4% (2024 JCR).