研究領域

利用多維異核核磁共振技術從結構的觀點探討生物巨分子之功能。「動脈粥狀硬化」和「阿茲海默症」等老年退化性疾病相關的生物巨分子之結構生物學研究，例如載脂蛋白E(apolipoprotein E)與脂質交互作用之機制及β-類澱粉胜肽(β-amyloid peptide)聚集與阿茲海默症致病機制之關係；開發去泛素化酶(Ubiquitin specific protease, USP)之抑制劑，作為癌症藥物之先導化合物；探討磷酸化如何調控蛋白磷酸酶-1(protein phosphatase-1)與其蛋白抑制劑(protein inhibitors)之交互作用。

研究著作(2018-2023)

Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S.-S. Wang*, Shiu-Huey Chou* and Ta-Hsien Lin*, Developing targeted drug delivery carriers for breast cancer using glutathione-sensitive doxorubicin-coupled glycated bovine serum albumin nanoparticles, 2023, International Journal of Biological Macromolecules, 249, 126114. IF: 8.2, 5 yr IF: 7.8, Ranking (Polymer Science): 5/86, 5.2% (2022 JCR).

You-Ren Lai, Steven S.-S. Wang, Ti-Lun Hsu, Szu-Hui Chou, Su-Chun How* and Ta-Hsien Lin*, Application of Amyloid-Based Hybrid Membranes in Drug Delivery, 2023, Polymers, 15(6), 1444. IF: 5.0, 5 yr IF: 5.0, Ranking (Polymer Science): 16/86, 18% (2022 JCR).

You-Ren Lai, Jinn-Tsyy Lai, Steven S.-S. Wang*, Yung-Chih Kuo*, Ta-Hsien Lin*, Silver nanoparticle-deposited whey protein isolate amyloid fibrils as catalysts for the reduction of methylene blue, 2022, International Journal of Biological Macromolecules, 249, 126114. IF: 8.2, 5 yr IF: 7.8, Ranking (Polymer Science): 5/86, 5.2% (2022 JCR).

Shu-Shun Hsueh, Steven S.-S. Wang, Shu-Han Chen, Chia-Lin Wang, Josephine W. Wu*, Ta-Hsien Lin*, Insights to Human D-Crystallin Unfolding by NMR Spectroscopy and Molecular Dynamics Simulations, 2022, International Journal of Molecular Sciences, 23, 1591. IF: 5.6, 5 yr IF: 6.2, Ranking (Biochemistry & Molecular Biology): 66/285, 23.0% (2022 JCR).

Hsu-Feng Chu, Shu-Chun Cheng, Chiao-Yin Sun, Chi-Yuan Chou, Ta-Hsien Lin*, Wei-Yi Chen*, Structural and Biochemical Characterization of PEDV Papain-like Protease 2, 2022, Journal of virology, 96, e01372-21. IF: 5.4, 5 yr IF: 4.9, Ranking (Virology): 11/36, 29.2% (2022 JCR).

Tai-Jay Chang*, Cheng-Yuan Hsia, Gar-Yang Chau, Liang-Tsai Hsiao, Kuang-Tzu Huanga, Kung-Liang King, Wing-Yiu Lui, Anna F.-Y Li, Chia-Lin Wang, Pin-Hsing Tsai, Yueh Chien, Ta-Hsien Lin*, Characterization of Androgen Receptor Complex Associated Protein (ARCAP) in Hepatocellular Carcinoma and Liver, 2021, Journal of the Chinese Medical Association, 84, 1100-1108. IF:3.0, 5 yr IF: 2.8, Ranking (Medicine, General & Internal): 75/167, 44.6% (2022 JCR).

Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu6 Ping-Hui Tseng, Greg G. Wang and Wei-Yi Chen, USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer, 2021, Cell Death and Disease, 12:880. IF: 9.0, 5 yr IF: 9.2, Ranking (Cell Biology): 31/191, 16.0% (2022 JCR).

Hsin-Cheng Lin, Ying Kuan, Hsu-Feng Chu, Shu-Chun Cheng, Heng-Chih Pan, Wei-Yi Chen, Chiao-Yin Sun*, Ta-Hsien Lin*, Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21, 2021, International Journal of Biological Macromolecules, 249, 126114. IF: 8.2, 5 yr IF: 7.8, Ranking (Polymer Science): 5/86, 5.2% (2022 JCR).

Su-Chun How, Ta-Hsien Lin*, Chun-Chao Chang*, Steven S.-S. Wang*, Examining the effect of bovine serum albumin on the properties and drug release behavior of β-lactoglobulin-derived amyloid fibril-based hydrogels, 2021, International Journal of Biological Macromolecules, 249, 126114. IF: 8.2, 5 yr IF: 7.8, Ranking (Polymer Science): 5/86, 5.2% (2022 JCR).

Shu-Shun Hsueh, Jian-Hong Lu, Josephine W. Wu*, Ta-Hsien Lin*, Steven S.-S. Wang*, Protection of human γD-crystallin protein from ultraviolet C-induced aggregation by ortho-vanillin, 2021, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 261, 120023. IF: 4.4, 5 yr IF: 3.9, Ranking (Spectroscopy): 5/41, 11.0% (2022 JCR).

Kai-Cyuan He, Yi-Ru Chen, Chu-Ting Liang, Shi-Jie Huang, Chung-Ying Tzeng, Chi-Fon Chang, Shing-Jong Huang, Hsien-Bin Huang*, Ta-Hsien Lin*, Conformational Characterization of Native and L17A/F19A-Substituted Dutch-Type β-Amyloid Peptides, 2020, International Journal of Molecular Sciences, 23, 1591. IF: 5.6, 5 yr IF: 6.2, Ranking (Biochemistry & Molecular Biology): 66/285, 23.0% (2022 JCR).

Yu-Shan Lin, Kuang-Yung Huang, Hui-Chun Yu, Ming-Chi Lu, Cheng-Jhong Fan, Hsien-Yu Huang Tseng, Bi-Yao Jhuang, Su-Qin Liu, Ning-Sheng Lai*, Ta-Hsien Lin*, Hsien-Bin Huang*, Identification of phostensin in association with Eps 15 homology domain-containing protein 1 and 4, 2020, Biochemical and Biophysical Research Communications, 531, 236-241. IF: 3.1, 5 yr IF: 3.2, Ranking (Biophysics): 33/70, 46.4% (2022 JCR).

De-Ming Yang*, Tai-Jay Chang, Mong-Lien Wang, Ping-Hsing Tsai, Ta-Hsien Lin, Chin-Tien Wang, Kung-Hao Liang, Hunting severe acute respiratory syndrome coronavirus 2 (2019 novel coronavirus): From laboratory testing back to basic research, 2020, Journal of the Chinese Medical Association, 84, 1100-1108. IF: 3.0, 5 yr IF: 2.8, Ranking (Medicine, General & Internal): 75/167, 44.6% (2022 JCR).

Tai-Jay Chang*, De-Ming Yang, Mong-Lien Wang, Kung-How Liang, Ping-Hsing Tsai, Shih-Hwa Chiou, Ta-Hsien Lin, Chin-Tien Wang, Genomic analysis and comparative multiple sequences of SARS-CoV2, 2020, Journal of the Chinese Medical Association, 84, 1100-1108. IF: 3.0, 5 yr IF: 2.8, Ranking (Medicine, General & Internal): 75/167, 44.6% (2022 JCR).

Kung-Hao Liang, Tai-Jay Chang, Mong-Lien Wang, Ping-Hsing Tsai, Ta-Hsien Lin, Chin-Tien Wang, De-Ming Yang*, Novel biosensor platforms for the detection of coronavirus infection and severe acute respiratory syndrome coronavirus 2, 2020, Journal of the Chinese Medical Association, 84, 1100-1108. IF: 3.0, 5 yr IF: 2.8, Ranking (Medicine, General & Internal): 75/167, 44.6% (2022 JCR).

Ping-Hsing Tsai, Mong-Lien Wang, De-Ming Yang, Kung-How Liang, Shih-Jie Chou, Shih-Hwa Chiou, Ta-Hsien Lin, Chin-Tien Wang, Tai-Jay Chang*, Genomic variance of Open Reading Frames (ORFs) and Spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 2020, Journal of the Chinese Medical Association, 84, 1100-1108. IF: 3.0, 5 yr IF: 2.8, Ranking (Medicine, General & Internal): 75/167, 44.6% (2022 JCR).

Chu-Ting Liang, Yu-Shan Lin, Yi-Choang Huang, Hsien-Lu Huang, Jia-Qian Yang, Tsung-Hsien Wu, Chi-Fon Chang, Shing-Jong Huang, Hsien-Bin Huang*, Ta-Hsien Lin* Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy, 2018, Scientific Reports, 8, Article number:50, IF: 4.6, 5 yr IF: 4.9, Ranking (Multidisciplinary Sciences): 22/73, 29.5% (2022 JCR).

Su-Chun How, Yu-Hong Cheng, Chun-Hsien Lo, Jinn-Tsyy Lai, Ta-Hsien Lin, Zuzana Bednarikova, Andrea Antosova, Zuzana Gazova*, Josephine W.Wu**, Steven S.-S. Wang***, Exploring the effects of methylene blue on amyloid fibrillogenesis of lysozyme, 2018, International Journal of Biological Macromolecules, 249, 126114. IF: 8.2, 5 yr IF: 7.8, Ranking (Polymer Science): 5/86, 5.2%(2022 JCR).